Results 21 to 30 of about 103,602 (308)

FOP is a centriolar satellite protein involved in ciliogenesis. [PDF]

PLoS ONE, 2013
Centriolar satellites are proteinaceous granules that are often clustered around the centrosome. Although centriolar satellites have been implicated in protein trafficking in relation to the centrosome and cilium, the details of their function and ...
Joanna Y Lee, Tim Stearns
doaj   +1 more source

MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing

Frontiers in Oncology, 2023
Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the establishment of de
Tamara Vital, Tamara Vital, Aminah Wali, Aminah Wali, Kyle V. Butler, Kyle V. Butler, Kyle V. Butler, Yan Xiong, Yan Xiong, Yan Xiong, Joseph P. Foster, Joseph P. Foster, Shelsa S. Marcel, Shelsa S. Marcel, Andrew W. McFadden, Valerie U. Nguyen, Benton M. Bailey, Kelsey N. Lamb, Lindsey I. James, Lindsey I. James, Stephen V. Frye, Stephen V. Frye, Amber L. Mosely, Amber L. Mosely, Jian Jin, Jian Jin, Jian Jin, Samantha G. Pattenden, Samantha G. Pattenden, Ian J. Davis, Ian J. Davis, Ian J. Davis   +31 more
doaj   +1 more source

Expression of C-terminal ALK, RET, or ROS1 in lung cancer cells with or without fusion

BMC Cancer, 2019
Background Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of anaplastic lymphoma kinase (ALK), RET proto-oncogene (RET), or v-ros UR2 sarcoma virus oncogene ...
Koh Furugaki, Marie Mochizuki, Mirei Kohno, Sei Shu, Naoki Harada, Yasushi Yoshimura   +5 more
doaj   +1 more source

Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview

Revista Brasileira de Hematologia e Hemoterapia, 2015
Myeloproliferative neoplasms are caused by a clonal proliferation of a hematopoietic progenitor. First described in 1951 as 'Myeloproliferative Diseases' and reevaluated by the World Health Organization classification system in 2011, myeloproliferative ...
Renata Mendes de Freitas, Carlos Magno da Costa Maranduba   +1 more
doaj   +1 more source

Orchestration of autophagosome fusion by STRIPAK complex components in muscle tissue

Autophagy Reports, 2023
Autophagy is a central process responsible for the disposal of normal as well as damaged cellular proteins and organelles. Proper regulation of multiple steps – including initiation and the fusion between autophagosomes and lysosomes – is essential for ...
Yungui Guo, Erika R. Geisbrecht
doaj   +1 more source

Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins [PDF]

Cancer Research, 2019
Abstract Chromosomal rearrangements involving receptor tyrosine kinases (RTK) are a clinically relevant oncogenic mechanism in human cancers. These chimeric oncoproteins often contain the C-terminal kinase domain of the RTK joined in cis to various N-terminal, nonkinase fusion partners.
Dana S. Neel, David V. Allegakoen, Victor Olivas, Manasi K. Mayekar, Golzar Hemmati, Nilanjana Chatterjee, Collin M. Blakely, Caroline E. McCoach, Julia K. Rotow, Anh Le, Niki Karachaliou, Rafael Rosell, Jonathan W. Riess, Robert Nichols, Robert C. Doebele, Trever G. Bivona   +15 more
openaire   +5 more sources

From discovery of tyrosine phosphorylation to targeted cancer therapies: The 2018 Tang Prize in Biopharmaceutical Science

Biomedical Journal, 2019
Protein tyrosine kinases (TKs) are a family of enzymes that catalyze the phosphorylation of proteins at tyrosine residues. TKs play key roles in controlling cell growth and many other functions by modulating the status of tyrosine phosphorylation of ...
Jau-Song Yu
doaj   +1 more source

DRP1 Promotes BRAFV600E-Driven Tumor Progression and Metabolic Reprogramming in Colorectal Cancer

Frontiers in Oncology, 2021
BackgroundMitochondria are highly dynamic organelles which remain in a continuous state of fission/ fusion dynamics to meet the metabolic needs of a cell. However, this fission/fusion dynamism has been reported to be dysregulated in most cancers.
Rayees Ahmad Padder, Zafar Iqbal Bhat, Zaki Ahmad, Neetu Singh, Mohammad Husain   +4 more
doaj   +1 more source

The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11)

Haematologica, 2011
We report a patient with T-lymphoblastic leukemia/lymphoma and a t(7;8)(q22;p11). CUX1 was identified as the fusion partner of FGFR1 by fluorescence in situ hybridization and 5′ RACE-PCR.
Bartosz Wasag, Els Lierman, Peter Meeus, Jan Cools, Peter Vandenberghe   +4 more
doaj   +1 more source

Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner [PDF]

Leukemia, 2015
Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent ...
S, He, B, Malik, D, Borkin, H, Miao, S, Shukla, K, Kempinska, T, Purohit, J, Wang, L, Chen, B, Parkin, S N, Malek, G, Danet-Desnoyers, A G, Muntean, T, Cierpicki, J, Grembecka   +14 more
openaire   +2 more sources