Results 11 to 20 of about 103,266 (261)

Detecting and targetting oncogenic fusion proteins in the genomic era [PDF]

Biology of the Cell, 2015
The advent of widespread cancer genome sequencing has accelerated our understanding of the molecular aberrations underlying malignant disease at an unprecedented rate. Coupling the large number of bioinformatic methods developed to locate genomic breakpoints with increased sequence read length and a deeper understanding of coding region function has ...
Monika A, Davare, Cristina E, Tognon
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One oncogene, several vulnerabilities: EWS/FLI targeted therapies for Ewing sarcoma

Journal of Bone Oncology, 2021
EWS/FLI is the defining mutation of Ewing sarcoma. This oncogene drives malignant transformation and progression and occurs in a genetic background characterized by few other recurrent cooperating mutations. In addition, the tumor is absolutely dependent
Guillermo Flores, Patrick J. Grohar
doaj   +1 more source

Mutation Profile of Well-Differentiated Thyroid Cancer in Asians [PDF]

Endocrinology and Metabolism, 2015
Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated with the mitogen-activated protein kinase ...
Young Shin Song, Jung Ah Lim, Young Joo Park   +2 more
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Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer. [PDF]

PLoS ONE, 2015
TMPRSS2-ERG junction oncogene is present in more than 50% of patients with prostate cancer and its expression is frequently associated with poor prognosis.
Giorgia Urbinati, Hafiz Muhammad Ali, Quentin Rousseau, Hubert Chapuis, Didier Desmaële, Patrick Couvreur, Liliane Massaad-Massade   +6 more
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Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein [PDF]

Oncogene, 2003
In Ewing's sarcoma family tumors, the ets transcription factor gene FLI1 is rearranged with one EWS allele resulting in coexpression of germline EWS and chimeric EWS-FLI1 proteins. Here, we investigated the potential of germline EWS, FLI1 and EWS-FLI1 to oligomerize. In two functional in vivo tests, fluorescence resonance energy transfer (FRET) and the
Laura, Spahn, Christine, Siligan, Radostina, Bachmaier, Johannes A, Schmid, Dave N T, Aryee, Heinrich, Kovar   +5 more
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Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

Cell Reports, 2015
Transcription factor fusion proteins can transform cells by inducing global changes of the transcriptome, often creating a state of oncogene addiction.
Eleni M. Tomazou, Nathan C. Sheffield, Christian Schmidl, Michael Schuster, Andreas Schönegger, Paul Datlinger, Stefan Kubicek, Christoph Bock, Heinrich Kovar   +8 more
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MTAP-ANRIL gene fusion promotes melanoma epithelial-mesenchymal transition-like process by activating the JNK and p38 signaling pathways

Scientific Reports, 2023
Gene fusions caused by cytogenetic aberrations play important roles in the initiation and progression of cancers. The recurrent MTAP-ANRIL fusion gene was reported to have a frequency of greater than 7% in melanoma in our previous study.
Zhuoying Lin, Yu Lei, Mingyao Wen, Qin He, Dean Tian, Huaping Xie   +5 more
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FOP is a centriolar satellite protein involved in ciliogenesis. [PDF]

PLoS ONE, 2013
Centriolar satellites are proteinaceous granules that are often clustered around the centrosome. Although centriolar satellites have been implicated in protein trafficking in relation to the centrosome and cilium, the details of their function and ...
Joanna Y Lee, Tim Stearns
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MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing

Frontiers in Oncology, 2023
Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the establishment of de
Tamara Vital, Tamara Vital, Aminah Wali, Aminah Wali, Kyle V. Butler, Kyle V. Butler, Kyle V. Butler, Yan Xiong, Yan Xiong, Yan Xiong, Joseph P. Foster, Joseph P. Foster, Shelsa S. Marcel, Shelsa S. Marcel, Andrew W. McFadden, Valerie U. Nguyen, Benton M. Bailey, Kelsey N. Lamb, Lindsey I. James, Lindsey I. James, Stephen V. Frye, Stephen V. Frye, Amber L. Mosely, Amber L. Mosely, Jian Jin, Jian Jin, Jian Jin, Samantha G. Pattenden, Samantha G. Pattenden, Ian J. Davis, Ian J. Davis, Ian J. Davis   +31 more
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Oncogenic fusion protein FGFR2-PPHLN1: Requirements for biological activation, and efficacy of inhibitors [PDF]

Translational Oncology, 2020
Chromosomal translocations such as t(10;12)(q26,q12) are associated with intrahepatic cholangiocarcinoma, a universally fatal category of liver cancer. This translocation creates the oncogenic fusion protein of Fibroblast Growth Factor Receptor 2 joined to Periphilin 1.
Li, Fangda, Meyer, April N, Peiris, Malalage N, Nelson, Katelyn N, Donoghue, Daniel J   +4 more
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