Results 31 to 40 of about 103,602 (308)
Chromatin profiling reveals relocalization of lysine-specific demethylase 1 by an oncogenic fusion protein [PDF]
Epigenetics, 2020 ABSTRACT Pediatric cancers commonly harbor quiet mutational landscapes and are instead characterized by single driver events such as the mutation of critical chromatin regulators, expression of oncohistones, or expression of oncogenic fusion proteins.
Emily R. Theisen +7 more
openaire +5 more sources
C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis [PDF]
, 2006 Within a cell, the levels and activity of multiple pro- and anti-apoptotic molecules act in concert to regulate commitment to apoptosis. Whilst the balance between survival and death can be tipped by the effects of single molecules, cellular apoptosis ...
Blaydes, J.P. +3 more
core +1 more source
Frontiers in Oncology, 2020 Objective: Oncogenic echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) (EML4-ALK) fusion proteins found in non-small cell lung cancers (NSCLC) are constitutively phosphorylated and activated by dimerization via the ...
Noriko Hirai +5 more
doaj +1 more source
Potential roles of synaptotagmin family members in cancers: Recent advances and prospects
Frontiers in Medicine, 2022 With the continuous development of bioinformatics and public database, more and more genes that play a role in cancers have been discovered. Synaptotagmins (SYTs) are abundant, evolutionarily conserved integral membrane proteins composed of a short N ...
Huandan Suo, Nan Xiao, Kewei Wang
doaj +1 more source
Targeting the MLL complex in acute leukemia [PDF]
, 2014 Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core +1 more source
Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition [PDF]
, 2013 © 2013 Yasaei et al.; licensee BioMed Central Ltd.This article has been made available through the Brunel Open Access Publishing Fund.Telomeres, the physical ends of chromosomes, play an important role in preserving genomic integrity.
Slijepcevic, P +5 more
core +1 more source
PML/RARα Destabilization by Hyperthermia: A New Model for Oncogenic Fusion Protein Degradation?
Blood Cancer Discovery, 2021 Abstract Summary: In this issue, Maimaitiyiming and colleagues demonstrate thermic stress–induced PML/RARα oncogenic fusion protein destabilization driven by corepressor aggregation. Hyperthermia synergizes with PML/RARα degradation by arsenic trioxide (ATO) and may circumvent ATO-resistance in historic acute promyelocytic leukemia ...
Wu, Hsin Chieh +2 more
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Apoptosis resistance in chronic myelogenous leukemia [PDF]
Einstein (São Paulo), 2005 The chronic myeloid leukemia (CML) is the three-phasemyeloproliferative disorder, dependent on the expression of theoncoprotein Bcr-Abl, which is the product of the reciprocaltranslocation between chromosomes 9 and 22, resulting in thePhiladelphia ...
Fabíola Attié de Castro +4 more
doaj
Haematologica, 2013 Acute lymphoblastic leukemia in infants represents an aggressive malignancy associated with a high incidence (approx. 80%) of translocations involving the Mixed Lineage Leukemia (MLL) gene.
Emma M.C. Driessen +7 more
doaj +1 more source
Changes in TFG gene expression in bovine leucocytes transformed by Theileria annulata
Frontiers in Veterinary Science, 2022 Theileria annulata schizont-infected host cells in culture in vitro show unlimited proliferation similar to tumor cells; thus far, T. annulata and T. parva are the only eukaryotes that have been found to transform mammalian cells (immortalized).
Hong-xi Zhao +4 more
doaj +1 more source