Results 1 to 10 of about 93,323 (254)

MLL (myeloid/lymphoid or mixed lineage leukemia) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on MLL (myeloid/lymphoid or mixed lineage leukemia), with data on DNA, on the protein encoded, and where the gene is ...
Jl Huret
exaly   +10 more sources

Current Management of Chronic Myeloid Leukemia Myeloid Blast Phase

Clinical Medicine Insights: Oncology, 2022
Despite the major advancements in the management of chronic phase (CP) chronic myeloid leukemia (CML), blast crisis (BC) remains a major therapeutic challenge. BC can be myeloid, lymphoid, or mixed lineage with myeloid BC being the most common type.
Binoy Yohanan, Binsah George
doaj   +2 more sources

The interleukin-3 receptor CD123 targeted SL-401 mediates potent cytotoxic activity against CD34+CD123+ cells from acute myeloid leukemia/myelodysplastic syndrome patients and healthy donors

Haematologica, 2018
Diseases with clonal hematopoiesis such as myelodysplastic syndrome and acute myeloid leukemia have high rates of relapse. Only a small subset of acute myeloid leukemia patients are cured with chemotherapy alone. Relapse in these diseases occurs at least
Rajeswaran Mani, Swagata Goswami, Bhavani Gopalakrishnan, Rahul Ramaswamy, Ronni Wasmuth, Minh Tran, Xiaokui Mo, Amber Gordon, Donna Bucci, David M. Lucas, Alice Mims, Christopher Brooks, Adrienne Dorrance, Alison Walker, William Blum, John C. Byrd, Gerard Lozanski, Sumithira Vasu, Natarajan Muthusamy   +18 more
doaj   +2 more sources

Development of BCR-ABL1 Transgenic Zebrafish Model Reproducing Chronic Myeloid Leukemia (CML) Like-Disease and Providing a New Insight into CML Mechanisms

Cells, 2021
Zebrafish has proven to be a versatile and reliable experimental in vivo tool to study human hematopoiesis and model hematological malignancies. Transgenic technologies enable the generation of specific leukemia types by the expression of human oncogenes
Daniela Zizioli, Simona Bernardi, Marco Varinelli, Mirko Farina, Luca Mignani, Katia Bosio, Dario Finazzi, Eugenio Monti, Nicola Polverelli, Michele Malagola, Elisa Borsani, Giuseppe Borsani, Domenico Russo   +12 more
doaj   +2 more sources

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

EBioMedicine, 2017
Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells.
Isabel Gonçalves Silva, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Rohanah Hussain, Giuliano Siligardi, Giacomo Ceccone, Steffen M. Berger, Yuri A. Ushkaryov, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev   +14 more
doaj   +2 more sources

Chronic myeloid leukemia presenting with isolated central nervous system lymphoid blast crisis: A case report [PDF]

Rare Tumors
Background Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm driven by the Philadelphia chromosome, typically progressing through chronic, accelerated, and blast phases. Blast crisis may be myeloid or lymphoid.
Álvaro Zarama-Valenzuela, Monica Arévalo-Zambrano, Álvaro Cadena-Andrade, Alejandro Zárate-Mesa   +3 more
doaj   +2 more sources

Identification of leukemia-enriched signature through the development of a comprehensive pediatric single-cell atlas

Nature Communications
Single-cell transcriptome profiling enables unparalleled characterization of the heterogeneous microenvironment of pediatric leukemias. To facilitate comparative analyses and generate pediatric leukemia signatures, we collect, process, and annotate ...
Hope L. Mumme, Chenbin Huang, Denis Ohlstrom, Mojtaba Bakhtiari, Sunil S. Raikar, Deborah DeRyckere, Muna Qayed, Sharon M. Castellino, Daniel S. Wechsler, Christopher C. Porter, Douglas K. Graham, Swati S. Bhasin, Manoj Bhasin   +12 more
doaj   +2 more sources

From ALL to Myeloid and NK Malignancies: Operationalizing “ASNS-Low” for L-Asparaginase Repurposing and Combination Therapy [PDF]

Biomolecules
L-asparaginase (ASNase) is a paradigmatic amino-acid depletion therapy that induces systemic asparagine starvation and remains foundational in acute lymphoblastic leukemia (ALL).
Toshiyuki Kitoh
doaj   +2 more sources

Kinase Inhibition in Relapsed/Refractory Leukemia and Lymphoma Settings: Recent Prospects into Clinical Investigations

Pharmaceutics, 2021
Cancer is still a major barrier to life expectancy increase worldwide, and hematologic neoplasms represent a relevant percentage of cancer incidence rates.
Caio Bezerra Machado, Flávia Melo Cunha de Pinho Pessoa, Emerson Lucena da Silva, Laudreísa da Costa Pantoja, Rodrigo Monteiro Ribeiro, Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes, Raquel Carvalho Montenegro, Rommel Mário Rodriguez Burbano, André Salim Khayat, Caroline Aquino Moreira-Nunes   +10 more
doaj   +1 more source

Myeloid/Lymphoid Neoplasm with FGFR1 Rearrangement Presenting with Polycythemia Vera and T-cell Acute Lymphoblastic Leukemia.

Cancer Genetics, 2023
Myeloid/lymphoid neoplasm with fibroblast growth factor 1 rearrangements (MLN-FGFR1) represents a rare group of hematologic neoplasms, with approximately 100 cases reported to date.
Lisa M. Marinelli, Joshua T Romain, W. Ehman, V. Ortega, G. Velagaleti, Thomas F. Gibbons, Ashley E Nazario-Toole, A. Holmes   +7 more
semanticscholar   +1 more source