Results 11 to 20 of about 117,497 (280)

Development of BCR-ABL1 Transgenic Zebrafish Model Reproducing Chronic Myeloid Leukemia (CML) Like-Disease and Providing a New Insight into CML Mechanisms

Cells, 2021
Zebrafish has proven to be a versatile and reliable experimental in vivo tool to study human hematopoiesis and model hematological malignancies. Transgenic technologies enable the generation of specific leukemia types by the expression of human oncogenes
Daniela Zizioli, Simona Bernardi, Marco Varinelli, Mirko Farina, Luca Mignani, Katia Bosio, Dario Finazzi, Eugenio Monti, Nicola Polverelli, Michele Malagola, Elisa Borsani, Giuseppe Borsani, Domenico Russo   +12 more
doaj   +2 more sources

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells

EBioMedicine, 2017
Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells.
Isabel Gonçalves Silva, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Rohanah Hussain, Giuliano Siligardi, Giacomo Ceccone, Steffen M. Berger, Yuri A. Ushkaryov, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev   +14 more
doaj   +2 more sources

Identification of leukemia-enriched signature through the development of a comprehensive pediatric single-cell atlas

Nature Communications
Single-cell transcriptome profiling enables unparalleled characterization of the heterogeneous microenvironment of pediatric leukemias. To facilitate comparative analyses and generate pediatric leukemia signatures, we collect, process, and annotate ...
Hope L. Mumme, Chenbin Huang, Denis Ohlstrom, Mojtaba Bakhtiari, Sunil S. Raikar, Deborah DeRyckere, Muna Qayed, Sharon M. Castellino, Daniel S. Wechsler, Christopher C. Porter, Douglas K. Graham, Swati S. Bhasin, Manoj Bhasin   +12 more
doaj   +2 more sources

Myeloid/Lymphoid Neoplasm with FGFR1 Rearrangement Presenting with Polycythemia Vera and T-cell Acute Lymphoblastic Leukemia.

Cancer Genetics, 2023
Myeloid/lymphoid neoplasm with fibroblast growth factor 1 rearrangements (MLN-FGFR1) represents a rare group of hematologic neoplasms, with approximately 100 cases reported to date.
Lisa M. Marinelli, Joshua T Romain, W. Ehman, V. Ortega, G. Velagaleti, Thomas F. Gibbons, Ashley E Nazario-Toole, A. Holmes   +7 more
semanticscholar   +1 more source

Investigation of Expression Profile of Placenta-specific 1 (PLAC1) in Acute Myeloid and Lymphoid Leukemias

Avicenna journal of medical biotechnology, 2023
Background: Placenta-specific 1 (PLAC1) is one of the cancer-testis-placenta antigens that has no expression in normal tissue except placenta trophoblast and testicular germ cells, but is overexpressed in a variety of solid tumors.
Parasto Gholami, H. Asgarian-Omran, M. Yaghmaie, Jafar Mahmudian, Shirin Kianersi, Sina Salari, E. Zaboli, M. Jeddi-Tehrani, A. Zarnani, M. Shabani   +9 more
semanticscholar   +1 more source

Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions

Blood reviews, 2021
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by a reciprocal translocation [t(9;22)(q34;q11.2)] that leads to the fusion of ABL1 gene sequences (9q34) downstream of BCR gene sequences (22q11) and is cytogenetically visible as ...
A. Osman, M. Deininger
semanticscholar   +1 more source

Germline POT1 Variants Can Predispose to Myeloid and Lymphoid Neoplasms

Leukemia, 2021
To the Editor: Since the introduction of myeloid neoplasms with germline predisposition as a new category by the World Health Organization [1], the list of genes linked to predisposition to hematologic malignancies has continued to grow.
Tristan L Lim, David B. Lieberman, A. Davis, A. Loren, R. Hausler, Ashkan Bigdeli, Yimei Li, J. Powers, A. Raper, Regeneron Genetics Center, Shannon A. Carty, K. Nathanson, A. Bagg, E. Hexner, K. Maxwell, J. Morrissette, D. Babushok   +16 more
semanticscholar   +1 more source

The diagnostic challenges and clinical course of a myeloid/lymphoid neoplasm with eosinophilia and ZBTB20-JAK2 gene fusion presenting as B-lymphoblastic leukemia

Cold Spring Harbor molecular case studies, 2020
We report the diagnostic challenges and the clinical course of a patient with an extraordinary presentation of B-lymphoblastic leukemia (B-ALL) with eosinophilia. We identified a novel ZBTB20-JAK2 gene fusion as a chimeric RNA transcript using the Archer
Winston Y. Lee, R. Pfau, Sarah M Choi, Jiong Yang, Hong Xiao, E. Putnam, Russell J. H. Ryan, D. Bixby, Lina Shao   +8 more
semanticscholar   +1 more source

Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis [PDF]

, 2019
The Ten-eleven translocation (TET) enzymes regulate gene expression by promoting DNA demethylation and partnering with chromatin modifiers. TET2, a member of this family, is frequently mutated in hematological disorders.
Abdel-Wahab, Agathocleous, Anders, Asmar, Chen, Cimmino, Cimmino, Delhommeau, Deplus, Dominguez, Fabiani, Garcia-Manero, Gardin, Giagounidis, Goasguen, Issa, Ito, Ito, Ito, Ito, Jiao, Kim, Ko, Komrokji, Kosmider, Lemonnier, Li, Love, Moran-Crusio, Mouly, Pan, Purton, Quivoron, Reddy, Sato, Schneider, Song, Tahiliani, Tefferi, Trapnell, Wang, Wang, Williams, Wu, Yu, Zhang   +45 more
core   +1 more source

Radiation-induced myeloid leukemia in murine models. [PDF]

, 2014
The use of radiation therapy is a cornerstone of modern cancer treatment. The number of patients that undergo radiation as a part of their therapy regimen is only increasing every year, but this does not come without cost.
Davoren, Michael, Rivina, Leena, Schiestl, Robert H   +2 more
core   +2 more sources