Results 11 to 20 of about 93,323 (254)
Avicenna journal of medical biotechnology, 2023 Background: Placenta-specific 1 (PLAC1) is one of the cancer-testis-placenta antigens that has no expression in normal tissue except placenta trophoblast and testicular germ cells, but is overexpressed in a variety of solid tumors.
Parasto Gholami +9 more
semanticscholar +1 more source
Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions
Blood reviews, 2021 Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by a reciprocal translocation [t(9;22)(q34;q11.2)] that leads to the fusion of ABL1 gene sequences (9q34) downstream of BCR gene sequences (22q11) and is cytogenetically visible as ...
A. Osman, M. Deininger
semanticscholar +1 more source
Germline POT1 Variants Can Predispose to Myeloid and Lymphoid Neoplasms
Leukemia, 2021 To the Editor: Since the introduction of myeloid neoplasms with germline predisposition as a new category by the World Health Organization [1], the list of genes linked to predisposition to hematologic malignancies has continued to grow.
Tristan L Lim +16 more
semanticscholar +1 more source
Cold Spring Harbor molecular case studies, 2020 We report the diagnostic challenges and the clinical course of a patient with an extraordinary presentation of B-lymphoblastic leukemia (B-ALL) with eosinophilia. We identified a novel ZBTB20-JAK2 gene fusion as a chimeric RNA transcript using the Archer
Winston Y. Lee +8 more
semanticscholar +1 more source
DETECTION OF BCR-ABL PROTEIN IN CHRONIC MYELOID LEUKEMIA PATIENTS USING IMMUNOCYTOCHEMISTRY
The Iraqi Journal of Medical Sciences, 2016 Background: Chronic Myeloid leukemia (CML) is a myeloproliferetive disorder associated with chromosomal abnormality, Philadelphia chromosome (Ph), in more than 95% of CML patients. The resulting BCR-ABL fused gene is markers for this type of leukemia. In
Maysaa Abdul Razaq Dhahi +2 more
doaj +6 more sources
Liaquat Medical Research Journal, 2022 This study was aimed to compare hemostatic, fibrinolytic and thrombotic parameters in pre and post induction chemotherapy in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL).
Tehmina Nafees Sonia Khan +5 more
doaj +1 more source
Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]
, 2000 At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Mittermueller, J. +5 more
core +1 more source
The Journal of Clinical Investigation, 2023 The B cell leukemia/lymphoma 2 (BCL-2) inhibitor venetoclax is effective in chronic lymphocytic leukemia (CLL); however, resistance may develop over time.
Stephen Jun Fei Chong +23 more
doaj +1 more source
A dual origin for Bcr-Abl gene translocation/fusion as dynamics of synergism of the hematopoietic stem cell and hemangioblast in chronic myeloid leukemia [PDF]
, 2015 Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core +1 more source