Results 41 to 50 of about 93,323 (254)

Intrachromosomal amplification of chromosome 21 (iAMP21) detected by ETV6/RUNX1 FISH screening in childhood acute lymphoblastic leukemia: a case report

Revista Brasileira de Hematologia e Hemoterapia, 2013
Chromosome abnormalities that usually define high-risk acute lymphoblastic leukemia are the t(9;22)/ breakpoint cluster region protein-Abelson murine leukemia viral oncogene homolog 1, hypodiploid with < 44 chromosomes and 11q23/ myeloid/lymphoid ...
Daniela Ribeiro Ney Garcia, Alejandro Mauricio Arancibia, Raul C. Ribeiro, Marcelo Gerardin Poirot Land, Maria Luiza Macedo Silva   +4 more
doaj   +1 more source

Neoantigens in Hematologic Malignancies

Frontiers in Immunology, 2020
T cell cancer neoantigens are created from peptides derived from cancer-specific aberrant proteins, such as mutated and fusion proteins, presented in complex with human leukocyte antigens on the cancer cell surface.
Melinda A. Biernacki, Melinda A. Biernacki, Marie Bleakley, Marie Bleakley   +3 more
doaj   +1 more source

BCL2 overexpression: clinical implication and biological insights in acute myeloid leukemia

Diagnostic Pathology, 2019
BackgroundBCL2 protein inhibitor venetoclax (ABT-199) has been authorized by Food and Drug Administration for relapsed/refractory chronic lymphoid leukemia with 17p deletion.
Jing‐dong Zhou, Ting-Juan Zhang, Zi-jun Xu, Yu Gu, Jichun Ma, Xi-xi Li, Hong Guo, Xiang-Mei Wen, Wei Zhang, Lei Yang, Xinglong Liu, Jiang Lin, J. Qian   +12 more
semanticscholar   +1 more source

CREB: A Key Regulator of Normal and Neoplastic Hematopoiesis

Advances in Hematology, 2009
The cAMP response element-binding protein (CREB) is a nuclear transcription factor downstream of cell surface receptors and mitogens that is critical for normal and neoplastic hematopoiesis.
Salemiz Sandoval, Martina Pigazzi, Kathleen M. Sakamoto   +2 more
doaj   +1 more source

Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition

Frontiers in Oncology, 2022
The zinc finger protein Growth Factor Independence 1 (GFI1) acts as a transcriptional repressor regulating differentiation of myeloid and lymphoid cells. A single nucleotide polymorphism of GFI1, GFI1-36N, has a prevalence of 7% in healthy Caucasians and
Jan Vorwerk, Kaiyan Sun, Daria Frank, Felix Neumann, Felix Neumann, Jana Hüve, Paulina Marie Budde, Longlong Liu, Xiaoqing Xie, Pradeep Kumar Patnana, Helal Mohammed Mohammed Ahmed, Bertram Opalka, Georg Lenz, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Cyrus Khandanpour, Cyrus Khandanpour   +19 more
doaj   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Proteomics of Acute Myeloid Leukemia [PDF]

, 2007
Acute Myeloid Leukemia (AML) is characterized by specific cytogenetic aberrations that are strong determinants of prognostic outcome and therapeutic response.
Yaseen, Mumtaz
core  

GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia

Stem Cell Research, 2016
Maintenance of hematopoietic stem cells and their potential to give rise to progenitors of differentiated lymphoid and myeloid cells are accomplished by a network of regulatory processes. As a part of this network, the heteromeric transcription factor GA-
Georgi Manukjan, Tim Ripperger, Letizia Venturini, Michael Stadler, Gudrun Göhring, Axel Schambach, Brigitte Schlegelberger, Doris Steinemann   +7 more
doaj   +1 more source

Pharmacological Targeting of BET Bromodomain Proteins in Acute Myeloid Leukemia and Malignant Lymphomas: From Molecular Characterization to Clinical Applications

Cancers, 2019
Alterations in protein-protein and DNA-protein interactions and abnormal chromatin remodeling are a major cause of uncontrolled gene transcription and constitutive activation of critical signaling pathways in cancer cells.
D. Reyes-Garau, M. Ribeiro, G. Roué
semanticscholar   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source