Results 31 to 40 of about 93,323 (254)

Targeting the MLL complex in acute leukemia [PDF]

, 2014
Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core   +1 more source

A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis

Cell Reports, 2018
Summary: Given its role as the source of definitive hematopoietic cells, we sought to determine whether mutations initiated in the hemogenic endothelium would yield hematopoietic abnormalities or malignancies.
Safiyyah Ziyad, Jesse D. Riordan, Ann M. Cavanaugh, Trent Su, Gloria E. Hernandez, Georg Hilfenhaus, Marco Morselli, Kristine Huynh, Kevin Wang, Jau-Nian Chen, Adam J. Dupuy, M. Luisa Iruela-Arispe   +11 more
doaj   +1 more source

SYK Inhibition Induces Apoptosis in Germinal Center-Like B Cells by Modulating the Antiapoptotic Protein Myeloid Cell Leukemia-1, Affecting B-Cell Activation and Antibody Production

Frontiers in Immunology, 2018
B cells play a major role in the antibody-mediated rejection (AMR) of solid organ transplants, a major public health concern. The germinal center (GC) is involved in the generation of donor-specific antibody-producing plasma cells and memory B cells ...
Nathalie Roders, Florence Herr, Gorbatchev Ambroise, O. Thaunat, A. Portier, A. Vazquez, A. Durrbach   +6 more
semanticscholar   +1 more source

Exploring downstream pathways of aberrantly activated kinases for targeted leukemia therapy [PDF]

, 2008
Genetic alterations resulting in uncontrolled protein tyrosine kinases (PTKs) activity are frequently found in leukemia and in human solid cancers. Although the development of small molecule kinase inhibitors has revolutionized therapy for PTKinduced ...
Gasser, Christelle
core   +1 more source

Prognostic Significance of the Lymphoblastic Leukemia-Derived Sequence 1 (LYL1) Gene Expression in Egyptian Patients with Acute Myeloid Leukemia

Turkish Journal of Hematology, 2014
OBJECTIVE: Aberrant activation of transcription factor genes is the most frequent target of genetic alteration in lymphoid malignancies. The lymphoblastic leukemia-derived sequence 1 (LYL1) gene, which encodes a basic helix-loop helix, was first ...
Nadia El Menshawy, Doaa Shahin, Hayam Fathi Ghazi   +2 more
doaj   +1 more source

Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure. [PDF]

PLoS ONE, 2013
Inactivation of the p53 pathway is a universal event in human cancers and promotes tumorigenesis and resistance to chemotherapy. Inactivating p53 mutations are uncommon in non-complex karyotype leukemias, thus the p53-pathway must be inactivated by other
Marcus M Schittenhelm, Barbara Illing, Figen Ahmut, Katharina Henriette Rasp, Gunnar Blumenstock, Konstanze Döhner, Charles D Lopez, Kerstin M Kampa-Schittenhelm   +7 more
doaj   +1 more source

Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis*

Journal of Biological Chemistry, 2012
Background: Recent GWA studies have demonstrated an association between the endocytic clathrin adaptor PICALM and Alzheimer disease. Results: Manipulation of PICALM expression selectively alters APP endocytosis and Aβ production in neural cells and ...
Qingli Xiao, S. Gil, Ping Yan, Yan Wang, Sharon Han, Ernie Gonzales, R. Perez, J. Cirrito, J. Lee   +8 more
semanticscholar   +1 more source

Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia

Haematologica, 2011
Background Dysfunctioning of CCAAT/enhancer binding protein α (C/EBPα) in acute myeloid leukemia can be caused, amongst others, by mutations in the encoding gene (CEBPA) and by promoter hypermethylation. CEBPA-mutated acute myeloid leukemia is associated
Iris H.I.M. Hollink, Marry M. van den Heuvel-Eibrink, Susan T.C.J.M. Arentsen-Peters, Martin Zimmermann, Justine K. Peeters, Peter J.M. Valk, Brian V. Balgobind, Edwin Sonneveld, Gertjan J.L. Kaspers, Eveline S.J.M. de Bont, Jan Trka, Andre Baruchel, Ursula Creutzig, Rob Pieters, Dirk Reinhardt, C. Michel Zwaan   +15 more
doaj   +1 more source

Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34⁺ cells to imatinib [PDF]

, 2009
<p><b>Objective:</b> To investigate the interaction of imatinib mesylate (IM) with the clinically relevant adenosine triphosphate-binding cassette efflux transporter MDR1 (ABCB1) in cells from patients with chronic myeloid leukemia (CML)
Holyoake, T.L., Jordanides, N.E., Jorgensen, H.G., Hatziieremia, S., Mountford, J.C.   +4 more
core   +1 more source

Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis

Haematologica, 2020
RAS-signaling mutations induce the myelomonocytic differentiation and proliferation of hematopoietic stem and progenitor cells. Moreover, they are important players in the development of myeloid neoplasias.
Veronica Caraffini, Olivia Geiger, Angelika Rosenberger, Stefan Hatzl, Bianca Perfler, Johannes L. Berg, Clarice Lim, Herbert Strobl, Karl Kashofer, Silvia Schauer, Christine Beham-Schmid, Gerald Hoefler, Klaus Geissler, Franz Quehenberger, Walter Kolch, Dimitris Athineos, Karen Blyth, Albert Wölfler, Heinz Sill, Armin Zebisch   +19 more
doaj   +1 more source