Results 1 to 10 of about 250 (73)

A novel four zinc-finger protein targeted against p190BcrAbl fusion oncogene cDNA: utilisation of zinc-finger recognition codes [PDF]

Nucleic Acids Research, 2000
A three zinc-finger protein that binds specifically to the cDNA representing the unique fusion gene BCR:Abl, associated with acute lymphoblastic leukaemia, has previously been characterised. At this breakpoint, a sequence homology of 8/9 bp exists between the BCR:Abl (fusion) and c-ABL: (parental) target sequences.
McNamara, A R, Ford, K G
openaire   +5 more sources

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]

Leukemia, 2011
Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
Heather G Jørgensen
exaly   +3 more sources

‘”Why me, why now?” Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infection [PDF]

, 2016
BACKGROUND: The prevalence of nontuberculous mycobacterial (NTM) disease is rising. An understanding of known risk factors for disease sheds light on the immunological and physical barriers to infection, and how and why they may be overcome.
David M. Lowe, Lyn R. Ambrose, M. Alexandra Lake, Marc C. I. Lipman   +3 more
core   +7 more sources

Acute lymphoblastic leukemia with e1A3 BCR-ABL fusion protein: report of 2 cases and literature review

Di-san junyi daxue xuebao, 2021
Objective To investigate the laboratory and clinical characteristics of acute lymphoblastic leukemia (ALL) with e1a3 BCR-ABL fusion protein. Methods The clinical data, and results of bone marrow cytology, flow cytometry, karyotyping, fluorescence in situ
CHEN Siyu, DENG Xiaojuan, ZHANG Yuwei, GOU Yang, ZHANG Xi, PENG Xiangui, WANG Ping   +6 more
doaj   +1 more source

DETECTION OF BCR-ABL PROTEIN IN CHRONIC MYELOID LEUKEMIA PATIENTS USING IMMUNOCYTOCHEMISTRY

The Iraqi Journal of Medical Sciences, 2016
Background: Chronic Myeloid leukemia (CML) is a myeloproliferetive disorder associated with chromosomal abnormality, Philadelphia chromosome (Ph), in more than 95% of CML patients. The resulting BCR-ABL fused gene is markers for this type of leukemia. In
Maysaa Abdul Razaq Dhahi, Nidhal Abdul Mohaymen, Nabeel S. Murad   +2 more
doaj   +6 more sources

Effect of HSP90AB1 and CC domain interaction on Bcr-Abl protein cytoplasm localization and function in chronic myeloid leukemia cells

Cell Communication and Signaling, 2021
Background The fusion oncoprotein Bcr-Abl is mostly located in the cytoplasm, which causes chronic myeloid leukemia (CML). After moving into the nucleus, the fusion protein can induce apoptosis of CML cells.
Yuhang Peng, Zhenglan Huang, Fangzhu Zhou, Teng Wang, Ke Mou, Wenli Feng   +5 more
doaj   +1 more source

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source

Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention [PDF]

, 2014
Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat skeletal muscle as a serine/threonine kinase that phosphorylated and inactivated glycogen synthase.
A Ballin, A Belkhiri, A Cole, A Gandillet, A Ikegame, A Niida, A Silva, AB Ochoa-Hernández, AE Abrahamsson, AJ Valvezan, AM Coluccia, AM Martelli, AV Ougolkov, AV Ougolkov, AW Duncan, B Chen, B Lustig, BG Bitler, BG Mar, BW Doble, BW Doble, C Chen, C Evangelisti, C Gao, C Grimaldi, C Shepherd, C Simioni, C Stengel, C Sutherland, C Zhao, CH Jamieson, CM Hedgepeth, D ten Berge, D Xu, DM Ferkey, E Chalecka-Franaszek, E Rao, F Piazza, F Zhou, FH Heidel, G Davidson, G Fuka, G Jeannet, G Reddiconto, GN Bijur, H Clevers, H Kawazoe, H Liang, H Wang, H Yuan, HK Bone, HS Huang, IN Colaluca, J Asano, J Franca-Koh, J Huang, J Huang, J Huang, J McQueen, J Si, J Yeung, JA Diehl, JA Hartigan, JB Tuynman, JN Anastas, JP Alao, JR Woodgett, JS Blackburn, JY Lee, K Gupta, K Inoki, K Ito, K Ito, K MacAulay, K Tanaka, K Willert, K Yamamoto, KR Holloway, KV Pajcini, L Busino, L Espinosa, L Kockeritz, L Li, L Rossig, L Willems, LS Steelman, M Bennecib, M Bianchi, M Bolzoni, M Fereshteh, M G-Amlak, M Juhaszova, M Lesort, M Masiero, M Welcker, MB Major, MC MacNicol, MD Castellone, MJ Welham, MM Bakre, MP Soutar, MR Mirlashari, N Embi, N Kremenevskaja, N Rocques, N Sato, NA Riobo, O Kaidanovich-Beilin, OH Yilmaz, P Liu, P Ricci, Q Ding, QL Wu, R Majeti, R Mishra, R Schwarzer, R Wang, RG Morgan, RG Wickremasinghe, RS Stein, RV Bhat, S Fruchon, S Gurumurthy, S Ikeda, S Patel, S Pece, S Shin, S Song, S Van Coppernolle, S Xu, S Yoshioka, SE Ross, SK Nifoussi, SM Huang, SM Sykes, SS Kanwar, T Ito, T Reya, T Schwarz-Romond, T Shimura, TC Luis, TM Thornton, V Banerji, V Ramakrishnan, VW Ding, W Chen, WG Gunn, WT O'Brien, X Zeng, Y Fu, Y Gu, Y Wang, Y Zhao, Z Kovacevic, Z Wang   +154 more
core   +1 more source

Ectopic expression of snail and twist in Ph+ leukemia cells upregulates CD44 expression and alters their differentiation potential [PDF]

, 2017
Philadelphia chromosome-positive (Ph+) leukemia is characterized by reciprocal translocation between chromosomes 9 and 22. The resultant BCR/ABL fusion protein displays constitutive tyrosine kinase activity, leading to the induction of aberrant ...
Dally, Najib, Eshel, Elizabeth, Khamaisie, Hazem, Kidan, Noa, Mahajna, Jamal, Roitman, Shay, Ruimi, Nili, Ruthardt, Martin   +7 more
core   +1 more source

Successful Preservation of Native BCR::ABL1 in Chronic Myeloid Leukemia Primary Leukocytes Reveals a Reduced Kinase Activity [PDF]

, 2022
Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by the acquisition of t(9;22) generating the fusion tyrosine kinase BCR::ABL1. However, despite the crucial role of this protein in the dysregulation of numerous signal transduction ...
Boni, Christian, Bonifacio, Massimiliano, Boscarino, Diego, Krampera, Mauro, Paladin, Dino, Parker, Laurie L., Scaffidi, Luigi, Sorio, Claudio, Tomasello, Luisa, Vezzalini, Marzia   +9 more
core   +1 more source