Results 1 to 10 of about 6,591,759 (119)
Nilotinib based pharmacophore models for BCRABL. [PDF]
Bioinformation, 2012 Tyrosine kinase inhibitors have revolutionized the treatment of several malignancies, converting lethal diseases in a manageable aspect. Imitanib, a small molecule ABL kinase inhibitor is a highly effective therapy for early phase chronic myeloid ...
Sabitha K.
europepmc +3 more sources
Autophagic degradation determines the fate of T315I-mutated BCR-ABL protein
Haematologica, 2019 Marked clinical improvement has been achieved by the use of BCR-ABL-tyrosine kinase inhibitors; however, mutations in BCR-ABL are among the most common causes of resistance to these inhibitors.
Haruka Shinohara +3 more
doaj +2 more sources
Molecular, Cytogenetic, and Hematological Analysis of Chronic Myeloid Leukemia Patients and Discovery of Two Novel Translocations. [PDF]
Anal Cell Pathol (Amst), 2021 Chronic myeloid leukemia (CML) is a disease of hematopoietic stem cells and is caused by the balanced translocations among the long arms of chromosomes 9 and 22, which are called the Philadelphia (Ph) chromosome. In this study, 131 CML patients were enrolled.
Asif M +8 more
europepmc +2 more sources
Journal of Biological Chemistry, 1994 Activation of the c-abl protooncogene occurs in Abelson murine leukemia virus, Hardy-Zuckerman-2 feline sarcoma virus, and during the chromosomal translocation that generates the BCRABL fusion gene. The three genes exhibit varying degrees of transforming
S. K. Shore +3 more
exaly +2 more sources
Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion. [PDF]
Mol Cancer, 2017 Cornils K +8 more
europepmc +2 more sources
A Cell-Based Assay for Measuring Endogenous BcrAbl Kinase Activity and Inhibitor Resistance. [PDF]
PLoS One, 2016 Ouellette SB, Noel BM, Parker LL.
europepmc +2 more sources
p53 restoration kills primitive leukemia cells in vivo and increases survival of leukemic mice. [PDF]
Cell Cycle, 2013 Velasco-Hernández T +3 more
europepmc +2 more sources
ENVIRONMENT. TECHNOLOGIES. RESOURCES. Proceedings of the International Scientific and Practical Conference, 2023 Vitamin B12 blood level in patients with myeloma (C90 - International Classification of Diseases (ICD-10)), lymphocytic leukemia (C91) and myeloblastic leukemia (C92) prior and after the diagnosis and also BCR-ABL (fusion gene from breakpoint cluster ...
D. Gavars +4 more
semanticscholar +1 more source
Di-san junyi daxue xuebao, 2021 Objective To investigate the laboratory and clinical characteristics of acute lymphoblastic leukemia (ALL) with e1a3 BCR-ABL fusion protein. Methods The clinical data, and results of bone marrow cytology, flow cytometry, karyotyping, fluorescence in situ
CHEN Siyu +6 more
doaj +1 more source