Results 1 to 10 of about 903 (90)

DETECTION OF BCR-ABL PROTEIN IN CHRONIC MYELOID LEUKEMIA PATIENTS USING IMMUNOCYTOCHEMISTRY

The Iraqi Journal of Medical Sciences, 2016
Background: Chronic Myeloid leukemia (CML) is a myeloproliferetive disorder associated with chromosomal abnormality, Philadelphia chromosome (Ph), in more than 95% of CML patients. The resulting BCR-ABL fused gene is markers for this type of leukemia. In
Maysaa Abdul Razaq Dhahi, Nidhal Abdul Mohaymen, Nabeel S. Murad   +2 more
doaj   +6 more sources

In vitro inhibitory effects of imatinib mesylate on stromal cells and hematopoietic progenitors from bone marrow

Brazilian Journal of Medical and Biological Research, 2013
Imatinib mesylate (IM) is used to treat chronic myeloid leukemia (CML) because it selectively inhibits tyrosine kinase, which is a hallmark of CML oncogenesis.
P.B. Soares, T.S. Jeremias, M. Alvarez-Silva, M.A. Licinio, M.C. Santos-Silva, C.L. Vituri   +5 more
doaj   +1 more source

Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling

Journal of Neuroinflammation, 2019
Background The FDA-approved small-molecule drug dasatinib is currently used as a treatment for chronic myeloid leukemia (CML). However, the effects of dasatinib on microglial and/or astrocytic neuroinflammatory responses and its mechanism of action have ...
Ka-Young Ryu, Hyun-ju Lee, Hanwoong Woo, Ri-Jin Kang, Kyung-Min Han, HyunHee Park, Sang Min Lee, Ju-Young Lee, Yoo Joo Jeong, Hyun-Wook Nam, Youngpyo Nam, Hyang-Sook Hoe   +11 more
doaj   +1 more source

Investigating the Glycating Effects of Glucose, Glyoxal and Methylglyoxal on Human Sperm

Scientific Reports, 2018
Glycation is the non-enzymatic reaction between reducing sugars, such as glucose, and proteins, lipids or nucleic acids, producing Advanced Glycation End (AGE) products.
Clare Nevin, Lauren McNeil, Nessar Ahmed, Chris Murgatroyd, Daniel Brison, Michael Carroll   +5 more
doaj   +1 more source

MEK1/2 regulate normal BCR and ABL1 tumor-suppressor functions to dictate ATO response in TKI-resistant Ph+ leukemia. [PDF]

Leukemia, 2023
Mazzera L, Abeltino M, Lombardi G, Cantoni AM, Jottini S, Corradi A, Ricca M, Rossetti E, Armando F, Peli A, Ferrari A, Martinelli G, Scupoli MT, Visco C, Bonifacio M, Ripamonti A, Gambacorti-Passerini C, Bonati A, Perris R, Lunghi P.   +19 more
europepmc   +1 more source

Brassinin Induces Apoptosis, Autophagy, and Paraptosis via MAPK Signaling Pathway Activation in Chronic Myelogenous Leukemia Cells. [PDF]

Biology (Basel), 2023
Yang MH, Ha IJ, Lee SG, Lee J, Um JY, Sethi G, Ahn KS.   +6 more
europepmc   +1 more source

Methyl-Thiol-Bridged Oxadiazole and Triazole Heterocycles as Inhibitors of NF-κB in Chronic Myelogenous Leukemia Cells. [PDF]

Biomedicines, 2023
Basappa B, Jung YY, Ravish A, Xi Z, Swamynayaka A, Madegowda M, Pandey V, Lobie PE, Sethi G, Ahn KS.   +9 more
europepmc   +1 more source

Ozonated Sunflower Oil Exerted Potent Anti-Inflammatory Activities with Enhanced Wound Healing and Tissue Regeneration Abilities against Acute Toxicity of Carboxymethyllysine in Zebrafish with Improved Blood Lipid Profile. [PDF]

Antioxidants (Basel), 2023
Cho KH, Kim JE, Bahuguna A, Kang DJ.
europepmc   +1 more source

CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation. [PDF]

Front Immunol, 2022
Kim JY, Kim J, Huang M, Kosonen R, Lee JE.   +4 more
europepmc   +1 more source

Inflammation Promotes Oxidative and Nitrosative Stress in Chronic Myelogenous Leukemia. [PDF]

Biomolecules, 2022
Đikić D, Bogdanović A, Marković D, Mitrović-Ajtić O, Subotički T, Diklić M, Vukotić M, Dragojević T, Živković E, Santibanez JF, Čokić VP.   +10 more
europepmc   +1 more source