Results 31 to 40 of about 53,103 (125)

Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION This study investigates ancestry‐specific changes in induced pluripotent stem cell (iPSC)‐derived oligodendroglia genomic regulation in Alzheimer's disease (AD), addressing diversity gaps by including African, Amerindian, and European ancestries in the analysis. METHODS We generated 12 iPSC lines from AD patients and controls with
Aura M. Ramirez, Luciana Bertholim Nasciben, Sofia Moura, Lauren Coombs, Farid Rajabli, Brooke A. DeRosa, Patrice L. Whitehead, Larry D. Adams, Takiyah D. Starks, Pedro R. Mena, Maryenela Illanes‐Manrique, Sergio Tejada, Goldie S. Byrd, Allison Caban‐Holt, Michael L Cuccaro, Katalina McInerney, Mario R. Cornejo‐Olivas, Briseida E. Feliciano‐Astacio, Liyong Wang, Maria C. Robayo, Wanying Xu, Fulai Jin, Margaret A. Pericak‐Vance, Anthony J. Griswold, Juan I. Young, Derek M. Dykxhoorn, Jeffery M. Vance   +26 more
wiley   +1 more source

Intracellular and Extracellular Vesicle miRNA Signatures in Human iPSC‐Derived Neural Stem Cells and Floor Plate Progenitors

The FASEB Journal, Volume 39, Issue 16, 31 August 2025.
Human induced pluripotent stem cells were differentiated into neural stem cells and floor plate progenitors of dopaminergic neurons, followed by microRNA profiling. While intracellular differences were limited, extracellular vesicle microRNAs showed 27 differentially expressed microRNAs and five consistently enriched across lineages.
Lilian Cruz, Frederico Moraes Ferreira, Camila Miranda Lopes‐Ramos, Zhiyun Wei, William T. Hendriks, H. A. Jinnah, Helder I. Nakaya, D. Cristopher Bragg, Anna M. Krichevsky, Xandra Owens Breakefield, Marilene Hohmuth Lopes   +10 more
wiley   +1 more source

Detection of BCR-ABL kinase domain mutations in CD34+ cells from newly diagnosed chronic phase CML patients and their association with imatinib resistance [PDF]

, 2011
BCR-ABL kinase domain (KD) mutations, the most common cause of imatinib resistance, are infrequently detected in newly diagnosed chronic-phase chronic myeloid leukemia (CP-CML) patients.
Riaz ul-Haq, Abdul Qayyum, Mubashar Naqvi, Tariq Gill, Muhammad Khalid, Ammara Tahir, Abid Jamil, Ahmad Khalid, Mahwish Khan, Muhammad Ferhan, Ijaz Shah, Abid Taj, Weng Qin, Mudassar Iqbal, Muhammad Abbad, Aamer Aleem, Tanveer Akhtar, Zafar Iqbal, Najeeb ur-Rehman, Shahid Baig   +19 more
core  

High-risk additional chromosomal abnormalities at low blast counts herald death by CML

, 2020
Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown.
Fabarius, Alice, Rinaldetti, Sebastien, Schlegelberger, Brigitte, Baccarani, Michele, Lauseker, Michael, Kalmanti, Lida, Pfirrmann, Markus, Kohlbrenner, Katharina, Voskanyan, Astghik, Hehlmann, Rüdiger, Haferlach, Claudia, for the SAKK and the German CML Study Group   +11 more
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Risk Assessment of toxic chemicals in ecosystems. Final report 'Ecosyteemrendement' [PDF]

, 2012
Dit rapport is een afsluiting van het project Ecosysteemrendement. Doel van dit project is de ontwikkeling van een onderzoeksinstrument om prioriteiten te kunnen stellen in het gebiedsgerichte stoffenbeleid door het berekenen van effecten op ecosystemen ...
Aldenberg T, Klijn F, Traas TP
core  

Impact of unbalanced minor route versus major route karyotypes at diagnosis on prognosis of CML

, 2015
Major route additional cytogenetic aberrations (ACA) at diagnosis of chronic myeloid leukaemia (CML) indicate an increased risk of progression and shorter survival.
Lindemann, Hans W., Goebeler, Maria-Elisabeth, Hofmann, W.K., Kneba, Michael, Hofmann, Wolf-Karsten, Schlegelberger, Brigitte, Hanfstein, Benjamin, Haferlach, C., Waller, Cornelius F., SAKK, SAKK,, Goebeler, M.E., Brümmendorf, Tim H., Stegelmann, F., Stegelmann, Frank, Edinger, Matthias, Seifarth, Wolfgang, Spiekermann, K., Dengler, Jolanta, Balleisen, L., Hehlmann, R., Hasford, Joerg, Kanz, Lothar, Brümmendorf, T.H., Rinaldetti, S., Burchert, A., Staib, Peter, Dietz, C.T., Kanz, L., Hehlmann, Rüdiger, Balleisen, Leopold, Pfreundschuh, M., Hänel, Mathias, Müller, M.C., Hochhaus, A., Kneba, M., Hasford, J., Köhne, Claus-Henning, Pfreundschuh, Michael, Lauseker, M., Fabarius, Alice, Krause, Stefan, Spiekermann, Karsten, Saußele, Susanne, Waller, C.F., Burchert, Andreas, German CML Study Group, Falge, Christiane, Haferlach, Claudia, Seifarth, W., Schlegelberger, B., Göhring, G., Krause, S., Berdel, Wolfgang E., Dengler, J., Edinger, M., Pfirrmann, Markus, Falge, C., Berdel, W.E., Jotterand, M., Hanfstein, B., Göhring, Gudrun, Kalmanti, L., Staib, P., Jotterand, Martine, Proetel, U., Müller, Martin C., Hochhaus, Andreas, Lindemann, H.W., Pfirrmann, M., Hänel, M., Köhne, C.H., Kalmanti, Lida, Lauseker, Michael, Dietz, Christian T., Fabarius, A., Rinaldetti, Sébastien, Proetel, Ulrike, Brümmendorf, Tim Henrik, Saußele, S.   +79 more
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Stemness and hybrid epithelial‐mesenchymal profiles guide peritoneal dissemination of malignant mesothelioma and pseudomyxoma peritonei

International Journal of Cancer, Volume 156, Issue 1, Page 201-215, 1 January 2025.
What's new? Factors involved in peritoneal dissemination of malignant mesothelioma (MM) and pseudomyxoma peritonei (PMP) are poorly characterized. Increased amounts of cancer stem cells identified high‐grade PMP and distinguished mass‐derived from ascitic/mucin‐associated cells in MM and PMP.
Nayana Lazzari, Giulia Rigotto, Barbara Montini, Paola Del Bianco, Elena Moretto, Federica Palladino, Rocco Cappellesso, Marco Tonello, Carola Cenzi, Antonio Scapinello, Maria Assunta Piano, Carlo Riccardo Rossi, Piero Dalerba, Pierluigi Pilati, Antonio Sommariva, Maria Luisa Calabrò   +15 more
wiley   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +2 more sources

Ependymal cells undergo astrocyte‐like reactivity in response to neuroinflammation

Journal of Neurochemistry, Volume 168, Issue 10, Page 3449-3466, October 2024.
Ependymal cells are unique glia that regulate local cerebrospinal fluid (CSF) microcirculation and form a dynamic interface between the brain and CSF. Here, we describe an unrecognized astrocyte‐like reactive transcriptomic profile that is assumed by ependymal cells in response to chronic neuroinflammation, that can be recapitulated following exposure ...
Adam M. R. Groh, Nina Caporicci‐Dinucci, Elia Afanasiev, Maxime Bigotte, Brianna Lu, Joshua Gertsvolf, Matthew D. Smith, Thomas Garton, Liam Callahan‐Martin, Alexis Allot, Dale J. Hatrock, Victoria Mamane, Sienna Drake, Huilin Tai, Jun Ding, Alyson E. Fournier, Catherine Larochelle, Peter A. Calabresi, Jo Anne Stratton   +18 more
wiley   +1 more source

CML-MSC-educated G-MDSC are immunosuppressive.

, 2016
A. HD- and CML-MSC generate similar amount of G-MDSC. The figure shows a representative data from one experiment. Flow cytometry analysis was performed with gates set on CD11b+CD33+CD15+CD14-HLADR- cell population. B.
Vincenzo Bramanti (2501365), Paolo Vigneri (230304), Alessandra Romano (596874), Piera La Cava (596873), Annalisa Chiarenza (596875), Daniele Tibullo (596872), Francesco Di Raimondo (207787), Nunziatina Laura Parrinello (3156843), Giuseppe Alberto Palumbo (3156846), Fabio Stagno (596878), Cesarina Giallongo (596870), Maria Violetta Brundo (618086)   +11 more
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