Results 31 to 40 of about 1,772 (132)
Regulation of BCL6: p38 MAPK signalling and CTCF transcriptional regulation converge at exon 1
, 2010 BCL6 is a zinc finger transcriptional repressor, which is highly expressed in germinal centre B-cells, and is essential for germinal centre formation and T-dependent antibody responses.
Batlle, Ana, Batlle, Ana
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Organization of the Proteostasis Network of Membraneless Organelles
Advanced Science, Volume 12, Issue 33, September 4, 2025.A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim +6 more
wiley +1 more source
Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease
Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.Abstract INTRODUCTION This study investigates ancestry‐specific changes in induced pluripotent stem cell (iPSC)‐derived oligodendroglia genomic regulation in Alzheimer's disease (AD), addressing diversity gaps by including African, Amerindian, and European ancestries in the analysis. METHODS We generated 12 iPSC lines from AD patients and controls with
Aura M. Ramirez +26 more
wiley +1 more source
Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants [PDF]
, 2008 Many chemotherapy drugs are known to cause significant clinical neurotoxicity, which can result in the early cessation of treatment. To identify and develop more effective means of neuroprotection it is important to understand the toxicity of these drugs
Burden, Hubert +7 more
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The FASEB Journal, Volume 39, Issue 16, 31 August 2025.Human induced pluripotent stem cells were differentiated into neural stem cells and floor plate progenitors of dopaminergic neurons, followed by microRNA profiling. While intracellular differences were limited, extracellular vesicle microRNAs showed 27 differentially expressed microRNAs and five consistently enriched across lineages.
Lilian Cruz +10 more
wiley +1 more source
A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis [PDF]
, 2003 The CCN (CYR61 [Cystein-rich61]/CTGF [connective tissue growth factor]/NOV [Nephroblastoma overexpressed]) proteins constitute a family of regulatory factors involved in many aspects of cell proliferation and differentiation.
Nathalie Planque, Bernard Perbal
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Pluripotent stem cells and their dynamic niche [PDF]
, 2016 Cell-seeded implants are a regenerative medicine strategy that aims to replace injured tissue and restore tissue function. Pluripotent stem cells are promising cell candidates for the development of regenerative medicine therapies as they have the ...
Bratt, J, El Haj, AJ, Reinwald, Y
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International Journal of Cancer, Volume 156, Issue 1, Page 201-215, 1 January 2025.What's new? Factors involved in peritoneal dissemination of malignant mesothelioma (MM) and pseudomyxoma peritonei (PMP) are poorly characterized. Increased amounts of cancer stem cells identified high‐grade PMP and distinguished mass‐derived from ascitic/mucin‐associated cells in MM and PMP.
Nayana Lazzari +15 more
wiley +1 more source
Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) [PDF]
, 2014 Acute myeloid leukemia (AML) is a life-threatening stem cell disease characterized by uncontrolled proliferation and accumulation of myeloblasts. Using an advanced RNAi screen-approach in an AML mouse model we have recently identified the epigenetic ...
Blatt, Katharina +11 more
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Ependymal cells undergo astrocyte‐like reactivity in response to neuroinflammation
Journal of Neurochemistry, Volume 168, Issue 10, Page 3449-3466, October 2024.Ependymal cells are unique glia that regulate local cerebrospinal fluid (CSF) microcirculation and form a dynamic interface between the brain and CSF. Here, we describe an unrecognized astrocyte‐like reactive transcriptomic profile that is assumed by ependymal cells in response to chronic neuroinflammation, that can be recapitulated following exposure ...
Adam M. R. Groh +18 more
wiley +1 more source