Results 11 to 20 of about 903 (90)
Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan +12 more
wiley +1 more source
Advanced Science, Volume 13, Issue 30, 28 May 2026.We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim +6 more
wiley +1 more source
Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7‐associated Alzheimer's disease risk
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION ABCA7 (ATP binding cassette subfamily A member 7) encodes a lipid transporter associated with increasing risk for Alzheimer's disease (AD). A 44‐base pair deletion in ABCA7 (rs142076058; p.Arg578Alafs) is a strong risk factor in individuals of African ancestry (AA).
Younji Nam +23 more
wiley +1 more source
Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions
MedComm, Volume 7, Issue 3, March 2026.Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu +9 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +3 more sources
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management
Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh +4 more
wiley +1 more source
Organization of the Proteostasis Network of Membraneless Organelles
Advanced Science, Volume 12, Issue 33, September 4, 2025.A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim +6 more
wiley +1 more source
Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease
Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.Abstract INTRODUCTION This study investigates ancestry‐specific changes in induced pluripotent stem cell (iPSC)‐derived oligodendroglia genomic regulation in Alzheimer's disease (AD), addressing diversity gaps by including African, Amerindian, and European ancestries in the analysis. METHODS We generated 12 iPSC lines from AD patients and controls with
Aura M. Ramirez +26 more
wiley +1 more source
The FASEB Journal, Volume 39, Issue 16, 31 August 2025.Human induced pluripotent stem cells were differentiated into neural stem cells and floor plate progenitors of dopaminergic neurons, followed by microRNA profiling. While intracellular differences were limited, extracellular vesicle microRNAs showed 27 differentially expressed microRNAs and five consistently enriched across lineages.
Lilian Cruz +10 more
wiley +1 more source
International Journal of Cancer, Volume 156, Issue 1, Page 201-215, 1 January 2025.What's new? Factors involved in peritoneal dissemination of malignant mesothelioma (MM) and pseudomyxoma peritonei (PMP) are poorly characterized. Increased amounts of cancer stem cells identified high‐grade PMP and distinguished mass‐derived from ascitic/mucin‐associated cells in MM and PMP.
Nayana Lazzari +15 more
wiley +1 more source