Results 21 to 30 of about 53,103 (125)

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, Volume 15, Issue 18, 15 May 2026.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla Iglesias‐García, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival [PDF]

, 2012
Recent evidence suggests CML stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from ...
Allan, Elaine K., Mueller-Tidow, Carsten, Nicolini, Franck E., Bhatia, Ravi, Brunton, Valerie G, Myssina, Svetlana, Hamilton, Ashley, Mysina, Svetlana, Müller-Tidow, Carsten, Koschmieder, Steffen, Allan, Elaine K, Helgason, G. Vignir, Helgason, G Vignir, Brunton, Valerie G., Schemionek, Mirle, Zhang, Bin, Holyoake, Tessa L., Holyoake, Tessa L, Nicolini, Franck E   +18 more
core   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, Volume 13, Issue 30, 28 May 2026.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7‐associated Alzheimer's disease risk

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION ABCA7 (ATP binding cassette subfamily A member 7) encodes a lipid transporter associated with increasing risk for Alzheimer's disease (AD). A 44‐base pair deletion in ABCA7 (rs142076058; p.Arg578Alafs) is a strong risk factor in individuals of African ancestry (AA).
Younji Nam, Brooke A. DeRosa, Aura M. Ramirez, Biniyam A. Ayele, Patrice Whitehead‐Gay, Larry D. Adams, Charles G. Golightly, Takiyah D. Starks, Mayra Juliana Laverde‐Paz, Holly N. Cukier, Rufus Akinyemi, Fred Sarfo, Albert Akpalu, Michael L. Cuccaro, Scott M. Williams, Allison Caban‐Holt, Christiane Reitz, Jonathan L. Haines, Goldie S. Byrd, Farid Rajabli, Derek M. Dykxhoorn, Juan I. Young, Jeffery M. Vance, Margaret A. Pericak‐Vance   +23 more
wiley   +1 more source

Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu, Rou Xue, Xiangwen Luo, Jiangnan Liao, Zongbo Zhang, Jinhai Deng, Teng Liu, Xin Li, Zhe‐Sheng Chen, Mingzhu Yin   +9 more
wiley   +1 more source

Clinical and Psychological Factors to Consider in Achieving Treatment-Free Remission in Patients With Chronic Myeloid Leukemia

, 2021
Treatment of chronic myeloid leukemia (CML) has evolved dramatically in recent years. In this regard, the introduction of second-generation tyrosine kinase inhibitors (TKI) has revolutionized therapeutic goals, and it is now desirable to obtain ...
Sica, Simona, CML-TFR-ITA Working Grp, Abruzzese, Elisabetta, Annunziata, Mario, Luciano, Luigia, Breccia, Massimo   +5 more
core   +1 more source

cml-ie-lab/choice-of-model v1.0

, 2018
Examining the properties of different supply-use to input-output table transformation ...
cml-ie-lab
core   +2 more sources

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV

, 2011
The prognostic relevance of additional cytogenetic findings at diagnosis of chronic myeloid leukemia (CML) is unclear. The impact of additional cytogenetic findings at diagnosis on time to complete cytogenetic (CCR) and major molecular remission (MMR ...
Frank Stegelmann, Leitner, A., Hofmann, W.K., Hofmann, Wolf-Karsten, Kneba, Michael, Reiter, A., Schlegelberger, Brigitte, Hanfstein, Benjamin, Haferlach, C., Neubauer, Andreas, Andreas Neubauer, Benjamin Hanfstein, Brigitte Schlegelberger, Müller, Martin C, Claudia Haferlach, Ho, A.D., Michael Lauseker, Baerlocher, Gabriela M, Martine Jotterand, Waller, Cornelius F, Jung-Munkwitz, S., Karsten Spiekermann, Stegelmann, F., Stegelmann, Frank, Spiekermann, K., Susanne Jung-Munkwitz, Christiane Falge, Hehlmann, R., Hasford, Joerg, Kanz, Lothar, Rüdiger Hehlmann, Leitner, Armin, Joerg Hasford, Wolf-Karsten Hofmann, Anthony D. Ho, Susanne Saussele, Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung,, Alice Fabarius, Kanz, L., Gudrun Göhring, Schubert, Jörg, Hehlmann, Rüdiger, null null, Saussele, Susanne, Pfreundschuh, M., Schwaab, J., Hochhaus, A., Müller, M.C., Martin C. Müller, Kneba, M., Gabriela M. Baerlocher, Hasford, J., Pfreundschuh, Michael, Lauseker, M., Fabarius, Alice, Armin Leitner, Jörg Schubert, Spiekermann, Karsten, Michael Kneba, Waller, C.F., Schwaab, Juliana, Haferlach, Claudia, Falge, Christiane, Schlegelberger, B., Juliana Schwaab, Göhring, G., Einsele, H., Ho, Anthony D, Pfirrmann, Markus, Neubauer, A., Jung-Munkwitz, Susanne, Falge, C., Reiter, Andreas, Baerlocher, G.M., Jotterand, M., Markus Pfirrmann, Hanfstein, B., Göhring, Gudrun, Hermann Einsele, Jotterand, Martine, Proetel, U., Andreas Reiter, Schubert, J., Hochhaus, Andreas, Pfirrmann, M., Lauseker, Michael, Ulrike Proetel, Fabarius, A., Michael Pfreundschuh, Saussele, S., Proetel, Ulrike, Einsele, Hermann, Andreas Hochhaus, Lothar Kanz, Cornelius F. Waller   +94 more
core   +1 more source

Organization of the Proteostasis Network of Membraneless Organelles

Advanced Science, Volume 12, Issue 33, September 4, 2025.
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim, Yuqi Bian, Alicia González Díaz, Frank Pun, Alex Zhavoronkov, Richard I. Morimoto, Michele Vendruscolo   +6 more
wiley   +1 more source