Results 41 to 50 of about 9,946,516 (158)

Ponatinib circumvents all types of imatinib resistance in chronic myelogenous leukemia cell lines

Cell Cycle, 2013
Chronic myelogenous leukemia (CML) is a hematopoietic stem cell disease characterized by the t(9; 22) q(34; q11) translocation encoding the oncoprotein BCR-ABL. Constitutive activation of the BCR-ABL tyrosine kinase is responsible for the exacerbation of
Maeva Dufies, O. Cassuto, A. Jacquel, G. Robert, P. Auberger   +4 more
semanticscholar   +1 more source

PS1175 DETECTING BCR‐ABL AND SCORING MR: RESULTS FROM A CE‐IVD KIT RUN ON NON‐IVD PCR INSTRUMENTS: A COMPARISON WITH DATA FROM A EUTOS VALIDATED LAB.

HemaSphere, Volume 3, Issue S1, Page 534-535, June 2019., 2019
Background: Detection of the BCR‐ABL1 fusion transcript in CML patients using RT‐qPCR allows sensitive monitoring of disease levels (minimal residual disease, MRD), which is important for determining prognosis and making treatment decisions. To interpret MRD results correctly in respect to data from clinical trials, it is necessary to report data as IS,
J. Petersen, G.W. Novotny
wiley   +1 more source

Immunodetection of Abl/BcrAbl, CrkL, and relevant site-specific phosphorylation.

, 2016
Lysates from parental (K), K562-IR (I), K562-NR (N) and K562-DR (D) cells cultured in the absence (K) or presence (I, N and D) of maintenance concentrations of their respective TKIs were analysed in duplicate using the Wes capillary immunodetection ...
Steven B. Ouellette (1649494), Laurie L. Parker (379405), Brett M. Noel (3106581)   +2 more
core   +1 more source

Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp. [PDF]

, 2012
The biophysical stability is an important parameter for protein activity both in vivo and in vitro. Here we propose a method to analyse thermal melting of protein domains in lysates: Fast parallel proteolysis (FASTpp).
Rüdiger, Stefan G. D., Stefan G D Rüdiger, Maurice, Madelon M., David P Minde, Sub Cellular Protein Chemistry, Stefan G. D. Rüdiger, Madelon M Maurice, Minde, David P., Cellular Protein Chemistry, David P. Minde, Madelon M. Maurice   +10 more
core   +3 more sources

Evaluation of Efficacy and Safety of Ponatinib as Third-line Treatment in Patients with the Diagnosis of Chronic Phase Chronic Myeloid Leukemia

, 2016
Philadelphia (Ph) is a fusion protein product of BCRABL and is a structurally active tyrosine kinase that causes chronic myeloid leukemia (CML) and a subgroup of acute lymphoblastic leukemia (ALL).1,2 Three tyrosine kinase inhibitors (TKI) (imatinib ...
P. Patir
semanticscholar   +1 more source

PB1953 QUALITY OF LIFE AND SYMPTOM BURDEN WITH FIRST AND SECOND GENERATION TYROSINE KINASE INHIBITORS IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA

HemaSphere, Volume 3, Issue S1, Page 887-888, June 2019., 2019
Background: With the advent of tyrosine kinase inhibitors (TKIs), patients with chronic myeloid leukemia (CML) have a life expectancy similar to those of age‐ and sex‐matched healthy population. Nevertheless, patients receiving TKIs report chronic adverse events, some of which may be associated with severe symptoms including fatigue, edema, muscle ...
T. Toptas, H. Bostan, K. Kut, F. Pepedil Tanrikulu, F. Yilmaz, I. Atagunduz, T. Tuglular   +6 more
wiley   +1 more source

Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein [PDF]

, 2001
The BCR-ABL oncogene is central in the pathogenesis of chronic myeloid leukemia (CML). Here, tandem nanospray mass spectrometry was used to demonstrate cell surface HLA- associated expression of the BCR-ABL peptide KQSSKALQR on class I-negative CIVIL ...
Lill, JR, Christmas, SE, Wang, LH, Macintyre, AR, Bourdon, A, Hill, SC, Rojas, J, Dodi, IA, Bonner, PLR, Aubert, G, Creaser, CS, Clark, RE, Rees, RC, Travers, PJ, Madrigal, JA   +14 more
core  

Non-Contiguous Protein Recombination [PDF]

, 2013
Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors and improved properties such as enhanced stability. Although homologous mutations are much more conservative than random mutations, chimeras of distantly-
Smith, Matthew Alexander
core   +1 more source

Abstract Book: 25th Congress of the European Hematology Association Virtual Edition, 2020

, 2020
HemaSphere, Volume 4, Issue S1, Page 1-1168, June 2020.
wiley   +1 more source

Analysis of Disulfide Bond Formation [PDF]

, 2017
In this unit, protocols are provided for detection of disulfide bond formation in cultures of intact cells and in an in vitro translation system containing isolated microsomes or semi-permeabilized cells.
Sub Cellular Protein Chemistry, Ineke Braakman, Hebert, Daniel N., Lydia Lamriben, Guus van Zadelhoff, van Zadelhoff, Guus, Braakman, Ineke, Daniel N. Hebert, Lamriben, Lydia, Cellular Protein Chemistry   +9 more
core   +2 more sources