Results 51 to 60 of about 9,946,516 (158)
An artificial immune system for clustering amino acids in the context of protein function classification [PDF]
, 2009 This paper addresses the classification task of data mining (a form of supervised learning) in the context of an important bioinformatics problem, namely the prediction of protein functions.
Timmis, Jon +5 more
core +1 more source
Unravelling the mechanisms of resistance to imatinib mesylate in chronic myeloid leukemia: a proteomic approach [PDF]
, 2010 Imatinib mesylate is a potent inhibitor of the Bcr-Abl tyrosine kinase, an oncoprotein that plays a key role in the development of chronic myeloid leukemia. Consequently, imatinib is used as front-line therapy for this disease.
Colavita, Irene
core +1 more source
Protein-RNA interactions: a structural analysis [PDF]
, 2001 A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT +9 more
core
Calcium as a crucial cofactor for low density lipoprotein receptor folding in the endoplasmic reticulum [PDF]
, 2010 The family of low density lipoprotein (LDL) receptors mediate uptake of a plethora of ligands from the circulation and couple this to signaling, thereby performing a crucial role in physiological processes including embryonic development, cancer ...
Sub Cellular Protein Chemistry +6 more
core +2 more sources
Pattern matching and pattern discovery algorithms for protein topologies [PDF]
, 2001 We describe algorithms for pattern matching and pattern learning in TOPS diagrams (formal descriptions of protein topologies). These problems can be reduced to checking for subgraph isomorphism and finding maximal common subgraphs in a restricted ...
Viksna, J +3 more
core +3 more sources
Characterization of assay reproducibility and validation using well-known BcrAbl inhibitors.
, 2016 (A) Positive (n = 93) and negative (n = 96) controls (positive control: maximal phosphorylation in the cell-based kinase activity assay; negative control: corresponding maximal inhibition by pre-incubation of cells with imatinib, 10 μM, followed by cell ...
Steven B. Ouellette (1649494) +2 more
core +1 more source
BcrAbl induced crossovers depend on the P3-motif of Fra.
, 2013 Stage 16 embryos stained with mAb 1D4 against Fasciclin II (FasII) are depicted with anterior up. All UAS (U) transgenes are pan-neurally expressed using the 1407-Gal4 (1407-G4) driver line recombined onto the fra3 chromosome; thus, phenotypes are ...
Joy N. Dorsten (366108) +4 more
core +1 more source
Choosing Targets for Gene Therapy
, 2011 Gene therapy is often attempted in fatal diseases with no known cure, or after standard therapies have failed. Targeting gene defects includes addressing a single mutation, multiple mutations in several genes, or even addressing missing or extra copies ...
Karina J. Matissek +3 more
semanticscholar +1 more source
Exploring Protein Sequence Space Using Computationally Directed Recombination [PDF]
, 2006 Evolution has provided us with many protein sequences. However, these sequences represent a very small fraction of the possible sequences. In the laboratory, scientists have explored areas of sequence space not represented by natural proteins both to ...
Meyer, Michelle Margaret
core +1 more source