Computational Insights into the Polypharmacological Landscape of BCR-ABL Inhibitors: Emphasis on Imatinib and Nilotinib [PDF]
Background: BCR-ABL inhibitors such as imatinib and nilotinib exhibit multi-kinase activity that extends beyond oncology, offering significant potential for drug repurposing.
Alhaded, Raghad +4 more
core +2 more sources
Iron Deficiency Caused by Intestinal Iron Loss-Novel Candidate Genes for Severe Anemia. [PDF]
Genes (Basel), 2021 Huettmann C +12 more
europepmc +1 more source
Establishment of a FDC-P1 Murine Cell Line with Human KIT N822K Gene Overexpression. [PDF]
Acta Naturae, 2020 Vagapova ER +5 more
europepmc +1 more source
TranSynergy: Mechanism-driven interpretable deep neural network for the synergistic prediction and pathway deconvolution of drug combinations. [PDF]
PLoS Comput Biol, 2021 Liu Q, Xie L.
europepmc +1 more source
BCR-ABL Tyrosine Kinase Domain Mutations Combinations Affects Imat inib Resistence in Chronic Phase Chronic Myelogenous Leukemia [PDF]
, 2019 Background: Chronic myelogenous leukemia is a myeloproliferative disease, due to reciprocal translocations of chromosome 9 and 22, resulting to Bcr-Abl fusion gene.
Amrita P N A +4 more
core
Senotherapeutics in Cancer and HIV. [PDF]
Cells, 2022 Sánchez-Díaz L +3 more
europepmc +1 more source
Targeting the cancer initiating cell : the ultimate target for cancer therapy [PDF]
, 2012 core +1 more source
Importance of Bioactive Secondary Metabolites in Orchids: A Review [PDF]
Introduction: Orchids are beautiful flowering plants rich in chemical constituents. The flowers of orchids persist for a very long period and fetch high prices in the market.
Kajal Choudhary, Shelja, Anukriti, Shailja, Jitender Kumar
core +1 more source
Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions. [PDF]
Nucleic Acids Res, 2018 Wu X +18 more
europepmc +1 more source
MicroRNA 30a Mediated Autophagy and Imatinib Response in Egyptian Chronic Myeloid Leukemia Patients. [PDF]
Indian J Hematol Blood Transfus, 2020 Khalil NA +4 more
europepmc +1 more source