Results 61 to 70 of about 9,946,516 (158)

Standardization of peptide concentration and cell number BcrAbl kinase activity assay.

, 2016
Peptide concentration and cell density were standardized for the cell-based BcrAbl kinase activity assay. BcrAbl kinase activity signal reported as relative fluorescent units (RFU, A-C) (A) Cells were exposed to a range of peptide concentrations (2.5–25 ...
Steven B. Ouellette (1649494), Laurie L. Parker (379405), Brett M. Noel (3106581)   +2 more
core   +1 more source

Computational Protein Design Force Field Optimization: A Negative Design Approach [PDF]

, 2007
An accurate force field is essential to computational protein design and protein folding studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state.
Alvizo, Oscar
core   +1 more source

Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells

Haematologica, 2002
BACKGROUND AND OBJECTIVES: The apoptotic Bcl-2 family member Hrk is transcriptionally silenced via DREAM in hematopoietic progenitor cell lines, and is specifically induced after growth factor withdrawal.
C Sanz, M Horita, JL Fernandez-Luna
doaj  

Correcting CFTR folding defects by small-molecule correctors to cure cystic fibrosis [PDF]

, 2017
Pharmacological intervention to treat the lethal genetic disease cystic fibrosis has become reality, even for the severe, most common folding mutant F508del CFTR. CFTR defects range from absence of the protein, misfolding that leads to degradation rather
Sub Cellular Protein Chemistry, Mijnders, Marjolein, Marjolein Mijnders, Ineke Braakman, Bertrand Kleizen, Braakman, Ineke, Cellular Protein Chemistry, Kleizen, Bertrand   +7 more
core   +1 more source

Proteosomal degradation of BCR/ABL protein can generate an HLA-A*0301-restricted peptide, but high-avidity T cells recognizing this leukemia-specific antigen were not demonstrated

Haematologica, 2004
BACKGROUND AND OBJECTIVES: Cytotoxic T-lymphocytes (CTL) have been generated in vitro against chronic myeloid leukemia (CML)-associated BCR/ABL-specific peptides.
EF Posthuma, CA van Bergen, MG Kester, RA de Paus, PA van Veelen, AH de Ru, JW Drijfhout, EG Lurvink, R Willemze, JH Falkenburg   +9 more
doaj  

“Abstracts of the 78th Annual Meeting of the Japanese Cancer Association; 2019 Sept 26‐28; Kyoto, Japan” as Cancer Science, Supplement 1, Vol 110 (2019)

, 2019
Cancer Science, Volume 110, Issue S1, Page 1-1208, December 2019.
wiley   +1 more source

Enhancing protein-protein docking by new approaches to protein flexibility and scoring of docking hypotheses [PDF]

, 2004
Zöllner FG. Enhancing protein-protein docking by new approaches to protein flexibility and scoring of docking hypotheses. Bielefeld (Germany): Bielefeld University; 2004.Für das Verständnis von biologischen Funktionen können Proteindockingverfahren ...
Frank G. Zöllner, Zöllner, Frank Gerrit   +1 more
core  

Alteration of protein function by a silent polymorphism linked to tRNA abundance [PDF]

, 2017
Synonymous single nucleotide polymorphisms (sSNPs) are considered neutral for protein function, as by definition they exchange only codons, not amino acids.
Sebastian Kirchner, Rauscher, Robert, Ostedgaard, Lynda S., Cai, Zhiwei, Ineke Braakman, Bertrand Kleizen, Cellular Protein Chemistry, Kleizen, Bertrand, Lynda S. Ostedgaard, Zoya Ignatova, Sub Cellular Protein Chemistry, Czech, Andreas, Ignatova, Zoya, Robert Rauscher, Zhiwei Cai, Braakman, Ineke, Anding, Melanie, Sheppard, David N., Lynda S Ostedgaard, Nicolai Kastelic, David N Sheppard, David N. Sheppard, Melanie Anding, Andreas Czech, Kirchner, Sebastian, Sheppard, David, Kastelic, Nicolai, Ostegaard, Lynda   +27 more
core   +2 more sources

Protein Docking mit weichen Volumenmodellen [PDF]

, 2003
Neumann S. Soft volume models for protein-protein docking. Bielefeld (Germany): Bielefeld University; 2003.Der Begriff "Protein Docking" beschreibt die Frage, ob und wie zwei gegebene Proteine interagieren, ausgehend von der 3D Struktur.
Neumann, Steffen
core  

Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells. [PDF]

Asian Pac J Cancer Prev, 2021
Al-Rawashde FA, Wan Taib WR, Ismail I, Johan MF, Al-Wajeeh AS, Al-Jamal HAN.   +5 more
europepmc   +1 more source