Results 51 to 60 of about 16,106 (168)
One Step Forward in the Challenging Arena of MLL-AF4 Leukemia [PDF]
Cancer Cell, 2016 MLL-AF4 leukemia is the predominant infant acute leukemia and has a poor prognosis. No current experimental models accurately reflect the human disease. Lin et al., in this issue of Cancer Cell, describe their model that recapitulates multiple key aspects of this aggressive disease, facilitating future mechanistic and preclinical studies.
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BMC Cancer, 2022 Purpose To evaluate the prognostic factors and outcome for acute lymphoblastic leukemia (ALL) in children with MLL rearrangement (MLL-r). Methods A total of 124 pediatric patients who were diagnosed with ALL were classified into two groups based on the ...
Kun-yin Qiu +8 more
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Modulation of cell cycle by graded expression of MLL-AF4 fusion oncoprotein [PDF]
Leukemia, 2004 Acute lymphoblastic leukemia (ALLs) expressing MLL-AF4, the fusion product of t(4;11)(q21;q23), show marked leucocytosis and extramedullary disease in multiple organs, respond poorly to chemotherapy and have poor prognosis. In vitro, leukemic cells with the t(4;11) show resistance to serum deprivation-induced or interferon gamma-regulated CD95-mediated
Caslini, C +4 more
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Romanian Journal of Laboratory Medicine, 2013 Introducere. Pacienţii cu leucemie acuta limfoblastică (LAL) neonatală prezintă în mod frecvent, o tran- slocaţie particulară, t(4;ll)(q21;q23), care duce la fuziunea genei MLL (mixed lineage leukemia) de pe cromo- zomul 11 cu gena AF4 de pe cromozomul 4.
Ivanov Iuliu C. +7 more
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Haematologica, 2019 B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of t(4;11)/KMT2A-AFF1+ (MLL-AF4+) infant
Antonio Agraz-Doblas +17 more
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bioRxiv, 2022 MLL-rearranged leukemias are among the leukemic subtypes with poorest survival, and treatment options have barely improved over the last decades. Furthermore, despite increasing molecular understanding of the mechanisms behind these hematopoietic ...
J. A. Johannessen +7 more
semanticscholar +1 more source
Cell Reports, 2013 The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans ...
Adam C. Wilkinson +11 more
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B-389 Validation of One-step In-house RT-qPCR Method for Detecting MLL::AF4 Fusion
Clinical Chemistry, 2023 Rearrangements of mixed lineage leukemia gene (MLL) with 1 of >130 alternative partner genes is a recurrent cytogenetic finding in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and is generally associated with a poor ...
F. K. Marques, D. A. Zauli
semanticscholar +1 more source
Stem Cell Research, 2023 KMT2A-AFF1 (MLL-AF4), formed by chromosomal translocation t(4;11), is observed specifically in infant pro-B acute lymphoblastic leukemia, and the main driver of leukemogenesis.
Masayuki Takahashi
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NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters. [PDF]
PLoS ONE, 2011 BackgroundDifferent histone post-translational modifications (PTMs) are crucial in the regulation of chromatin, including methylations of H3 at Lysine 4 by the MLL complex.
Andrea Fossati +3 more
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