Results 1 to 10 of about 1,137 (118)
Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia [PDF]
Cell, 2017 Chromosomal translocations of the mixed‐lineage leukemia ( MLL ) gene with various partner genes result in aggressive MLL leukemia with dismal outcomes. Despite relatively equal contributions of the rearranged allele and the remaining wild‐type allele at the mRNA level, the MLL chimeric ...
Jeffrey Haug +2 more
exaly +3 more sources
t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL [PDF]
Leukemia Research, 2011 The most frequent MLL-gene rearrangement found in leukemia is a reciprocal translocation with AF4 on chromosome 4 resulting in the formation of the MLL-AF4 and the AF4-MLL fusion genes. The oncogenic role of MLL-AF4 is documented but the significance of the reciprocal product - AF4-MLL in leukemia is less clear.
Ashish Kumar, John H Kersey
exaly +3 more sources
The MLL/SET family and haematopoiesis [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020 As demonstrated through early work in Drosophila, members of the MLL/SET family play essential roles during embryonic development through their participation in large protein complexes that are central to epigenetic regulation of gene expression. One of its members, MLL1, has additionally received a lot of attention as it is a potent oncogenic driver ...
Antunes, Eric, Ottersbach, Katrin
openaire +2 more sources
Got MLL? Definitive Hematopoiesis Requires MLL Gene Expression [PDF]
Molecular Cell, 2004 A manuscript by Ernst and colleagues in the March 2004 issue of Developmental Cell demonstrates that following hematopoietic stem cell appearance in the AGM, expression of the MLL transcription factor is required for their subsequent differentiation.
Dorshkind, Kenneth, Witte, Owen
openaire +2 more sources
No proof nets for MLL with units [PDF]
Proceedings of the Joint Meeting of the Twenty-Third EACSL Annual Conference on Computer Science Logic (CSL) and the Twenty-Ninth Annual ACM/IEEE Symposium on Logic in Computer Science (LICS), 2014 MLL proof equivalence is the problem of deciding whether two proofs in multiplicative linear logic are related by a series of inference permutations. It is also known as the word problem for *-autonomous categories. Previous work has shown the problem to be equivalent to a rewiring problem on proof nets, which are not canonical for full MLL due to the ...
Willem Heijltjes, Robin Houston
openaire +1 more source
A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition [PDF]
Cancer Discovery, 2021 ABSTRACT The chromatin adaptor Menin interacts with oncogenic fusion proteins encoded by MLL1 -rearrangements ( MLL1 -r), and small molecules that disrupt these associations are currently in clinical trials for the treatment of leukemia.
Yadira M. Soto-Feliciano +21 more
openaire +2 more sources
Haematologica, 2012 We investigated 15,542 patients with suspected BCR-ABL1- negative myeloproliferative or myelodysplastic/myeloproliferative neoplasm (including 359 chronic myelomonocytic leukemia) by a molecular marker set.
Susanne Schnittger +9 more
doaj +1 more source
Designed to Kill: Novel Menin-MLL Inhibitors Target MLL -Rearranged Leukemia [PDF]
Cancer Cell, 2015 The interaction between menin and oncogenic mixed lineage leukemia (MLL) fusion proteins is required for leukemic transformation and may represent a therapeutic opportunity. In this issue of Cancer Cell, Borkin and colleagues describe the development of highly potent small-molecule inhibitors of this interaction that reverse the leukemic phenotype and ...
Kühn, Michael W.M. +1 more
openaire +2 more sources
Paradoxical Effects of MLL Paralogs in MLL-Rearranged Leukemia [PDF]
Cancer Cell, 2017 Conflicting data exist on the requirement for wild-type MLL1 in MLL-rearranged leukemia. In this issue of Cancer Cell, Chen et al. describe complementary approaches demonstrating that MLL1 is dispensable for MLL-fusion-mediated leukemogenesis. They also observe an unexpected role for MLL2 in MLL-rearranged leukemia cells and identify potential ...
openaire +2 more sources
Haematologica, 2016 Chronic myeloid leukemia cells acquire resistance to tyrosine kinase inhibitors through mutations in the ABL1 kinase domain. The T315I mutation mediates resistance to imatinib, dasatinib, nilotinib and bosutinib, whereas sensitivity to ponatinib remains.
Constance Baer +7 more
doaj +1 more source