Results 41 to 50 of about 25,228 (245)

Metal‐Half‐Salen Chemistry for One‐Pot Mineralization on Hydrophobic Polymer Membranes

Advanced Science, EarlyView.
Here we report a versatile one‐pot synthetic strategy for organic–inorganic composite membranes, which leverages a metal half‐Salen system to precisely govern the competing kinetics of coordination and hydrolysis. In contrast to conventional two‐step metal‐phenol chemistries, our integrated approach substantially simplifies the fabrication process ...
Rou‐Ming Wen, Hao Ye, Ming‐Bang Wu, Lu‐Lin Ma, Qi‐Hui Ye, Zi‐Hao Yuan, Yi Xie, Juming Yao, Hao‐Cheng Yang   +8 more
wiley   +1 more source

Serial assessment of suspected myelodysplastic syndromes: significance of flow cytometric findings validated by cytomorphology, cytogenetics, and molecular genetics

Haematologica, 2013
The significance of flow cytometry indicating myelodysplasia without proof of myelodysplasia by cytomorphology remains to be clarified. We evaluated follow-up analyses in 142 patients analyzed in parallel by flow cytometry, cytomorphology and ...
Wolfgang Kern, Claudia Haferlach, Susanne Schnittger, Tamara Alpermann, Torsten Haferlach   +4 more
doaj   +1 more source

Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia. [PDF]

PLoS ONE, 2015
MLL-rearranged acute lymphoblastic leukemia (ALL) in infants (
Marieke H van der Linden, Lidija Seslija, Pauline Schneider, Emma M C Driessen, Patricia Garrido Castro, Dominique J P M Stumpel, Eddy van Roon, Jasper de Boer, Owen Williams, Rob Pieters, Ronald W Stam   +10 more
doaj   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

MolMiner: Toward Controllable, Three‐Dimensional‐Aware, Fragment‐Based Molecular Design

Advanced Intelligent Discovery, EarlyView.
MolMiner is a fragment‐based, geometry‐aware, and order‐agnostic generative model for molecular design with strong inductive biases. Using symmetry‐aware fragment assembly, dynamic three‐dimensional geometry, and multi‐property conditioning, MolMiner enables interpretable and controllable molecular generation.
Raul Ortega‐Ochoa, Tejs Vegge, Jes Frellsen   +2 more
wiley   +1 more source

Modified Neumann incision for implant placement in overdentures: Case series of a less invasive alternative

Clinical Advances in Periodontics, EarlyView.
Abstract Background Conventional envelope flap techniques for implant placement in edentulous mandibles are associated with greater postoperative morbidity, especially in elderly patients or those with anatomical limitations. Minimally invasive alternatives aim to preserve soft tissues and reduce complications, enhancing clinical predictability ...
Lucas Jardim da Silva, Laura Lourenço Morel, Luciana de Rezende Pinto, Otacílio Luiz Chagas‐Júnior, Jamil Awad Shibli, Fernanda Faot   +5 more
wiley   +1 more source

Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization

Blood, 2009
AbstractChromosomal translocations involving the Mixed Lineage Leukemia (MLL) gene produce chimeric proteins that cause abnormal expression of a subset of HOX genes and leukemia development. Here, we show that MLL normally regulates expression of mir-196b, a hematopoietic microRNA located within the HoxA cluster, in a pattern similar to that of the ...
Relja, Popovic, Laurie E, Riesbeck, Chinavenmeni S, Velu, Aditya, Chaubey, Jiwang, Zhang, Nicholas J, Achille, Frank E, Erfurth, Katherine, Eaton, Jun, Lu, H Leighton, Grimes, Jianjun, Chen, Janet D, Rowley, Nancy J, Zeleznik-Le   +12 more
openaire   +3 more sources

De Novo Design of Multivalent α/β‐Peptides Mimicking Transcription Factors Targeting the CBP KIX Domain

Chemistry – A European Journal, EarlyView.
A modular, de novo α/β‐peptide design strategy allows fine‐tuning of ligand properties, resulting in multivalent ligands that simultaneously target separate binding sites on the protein surface. ABSTRACT Protein‐protein interactions that regulate gene expression in the nucleus are increasingly recognized as potential therapeutic targets but present ...
Márk V. Tresztián, Vencel L. Petrovicz, Edit Wéber, Tamás A. Martinek, Zsófia Hegedüs   +4 more
wiley   +1 more source

3'UTR-mediated gene silencing of the Mixed Lineage Leukemia (MLL) gene. [PDF]

PLoS ONE, 2011
Translocations involving the Mixed Lineage Leukemia (MLL) gene generate in-frame fusions of MLL with more than 50 different partner genes (PGs). Common to all MLL translocations is the exchange not only of coding regions, but also of MLL and PG 3 ...
Maria Gomez-Benito, Fabricio Loayza-Puch, Joachim A F Oude Vrielink, Maria D Odero, Reuven Agami   +4 more
doaj   +1 more source

Rapid and Reusable Amino Acid–Derived MOFs for the Removal of Estrogenic Hormones From Real Water Matrices

Chemistry – A European Journal, EarlyView.
A family of amino‐acid–derived MOFs enables ultrafast (>90–95% in 30 s) simultaneous removal of four estrogenic contaminants from water under SPE conditions. A leucine‐based MOF shows excellent regenerability and robustness in real samples, with structural evidence revealing efficient hormone encapsulation.
Lidia García, Alejandro Cortés‐Villena, Héctor Martínez Pérez‐Cejuela, José Manuel Herrero‐Martínez, Jesús Ferrando‐Soria, Thais Grancha, Donatella Armentano, Emilio Pardo   +7 more
wiley   +1 more source