Results 61 to 70 of about 25,228 (245)
Small, EarlyView.The study introduces a 3D sensing‐integrated platform enabling real‐time, non‐invasive monitoring of pH dynamics in patient‐derived PDAC tumorspheres. It revealed distinct extracellular acidification patterns under FOLFIRINOX, gemcitabine, and paclitaxel, correlating with therapeutic efficacy.
Stefania Forciniti +10 more
wiley +1 more source
Smart Molecules, EarlyView.AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin +10 more
wiley +1 more source
Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models
Environmental Toxicology, EarlyView.ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa +9 more
wiley +1 more source
Decreased Production of Tissue Plasminogen Activator in Endothelial Cells From Nasal Polyps
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Introduction Previous studies have demonstrated that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition which is related to impaired production of tissue plasminogen activator(t‐PA) by epithelial cells.
Qian‐Qian Zhang +9 more
wiley +1 more source
Transcriptional addiction in mixed lineage leukemia: new avenues for target therapies
Blood Science, 2019 . Mixed lineage leukemia (MLL) is an aggressive and refractory blood cancer that predominantly occurs in pediatric patients and is often associated with poor prognosis and dismal outcomes.
Ruijing Xiao +2 more
doaj +1 more source
MLL Gene Alterations in Acute Myeloid Leukaemia (11q23/MLL+ AML)
, 2013 Acute myeloid leukemia (AML) is characterized by the malignant transformation of myeloid cells from myeloblasts to a pathological cell clone. These pathological cell clones lose their ability to differentiate and mature, are no longer subject to regulatory mechanisms and suppress other components of normal hemopoiesis.
Denisa Ilencikova, Alexandra Kolenov
openaire +2 more sources
Building Blocks as Experiences in Dynamic Capacitated Arc Routing Problems
CAAI Transactions on Intelligence Technology, EarlyView.ABSTRACT The dynamic capacitated arc routing problem (DCARP) aims to update the service paths of vehicles in the capacitated arc routing problem when uncertain factors deteriorate the current schedule of vehicles' services. A DCARP scenario comprises a series of DCARP instances that share similarities with each other. Therefore, optimisation experience
Hao Tong +4 more
wiley +1 more source
Journal of Synchrotron Radiation, EarlyView.A beamline‐direction cross‐vessel metrology method and error analysis for ptychography setup at HEPS ID09 is proposed and implemented. A 12.3 nm reconstruction resolution of ptychography demonstrates the validity of metrology.A metrology method dedicated to position monitoring and correction for the ptychography setup at the High Energy Photon Source ...
Ruiying Liao +10 more
wiley +1 more source