Results 21 to 30 of about 25,228 (245)

Classical meets malignant hematology: a case of acquired εγδβ-thalassemia in clonal hematopoiesis

Haematologica
Hemoglobinopathies including thalassemias are among the most frequent genetic disorders worldwide. Primarily, these entities result from germline variants in the globin gene clusters and their cis-acting regulatory elements, and thus the WHO classifies ...
Armin P. Piehler, Marietta Truger, Jan-Hendrik Kozik, Sandra Weissmann, Martin Schwonzen, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Gregor Hoermann, Claudia Haferlach   +9 more
doaj   +1 more source

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia [PDF]

Nature Chemical Biology, 2012
Translocations involving the mixed lineage leukemia (MLL) gene result in human acute leukemias with very poor prognosis. The leukemogenic activity of MLL fusion proteins is critically dependent on their direct interaction with menin, a product of the multiple endocrine neoplasia (MEN1) gene.
Jolanta, Grembecka, Shihan, He, Aibin, Shi, Trupta, Purohit, Andrew G, Muntean, Roderick J, Sorenson, Hollis D, Showalter, Marcelo J, Murai, Amalia M, Belcher, Thomas, Hartley, Jay L, Hess, Tomasz, Cierpicki   +11 more
openaire   +2 more sources

The PHD fingers of MLL block MLL fusion protein–mediated transformation

Blood, 2008
Abstract Chromosomal translocations involving the mixed lineage leukemia (MLL) gene are associated with aggressive acute lymphoid and myeloid leukemias. These translocations are restricted to an 8.3-kb breakpoint region resulting in fusion of amino terminal MLL sequences in frame to 1 of more than 60 different translocation partners. The
Andrew G, Muntean, Diane, Giannola, Aaron M, Udager, Jay L, Hess   +3 more
openaire   +3 more sources

MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele [PDF]

Cancer Cell, 2010
Oncogenic fusion proteins are capable of initiating tumorigenesis, but the role of their wild-type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) gene undergoes chromosomal translocations, resulting in the formation of oncogenic MLL fusion proteins (MLL-FPs).
Thiel, Austin T., Blessington, Peter, Zou, Tao, Feather, Danielle, Wu, Xinjiang, Yan, Jizhou, Zhang, Hui, Liu, Zuguo, Ernst, Patricia, Koretzky, Gary A., Hua, Xianxin   +10 more
openaire   +3 more sources

Adult TWIST2‐high B‐ALL confirms metabolic association but reveals molecular heterogeneity [PDF]

HemaSphere
Wencke Walter, Veronika Ecker, Wolfgang Kern, Anna Stengel   +3 more
doaj   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Acute pro-B-cell lymphoblastic leukemia evolving from myelodysplastic neoplasm post-cytotoxic therapy: a case report

Haematologica
Not available.
Jana Wobst, Marietta Truger, Constance Baer, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach   +6 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Morel-Lavallee Lesion (MLL) Mimicking A Soft Tissue Neoplasm [PDF]

Journal of Clinical and Diagnostic Research, 2015
Morel-lavallee lesion (MLL) represents post traumatic subcutaneous cyst generally overlying bony prominences like greater trochanter, lower back, knee and scapula.
SANDEEP KUMAR, ROUMINA HASAN, RAJAGOPAL KADAVIGERE, SATISH BABU MADDUKURI, RADHA PUPPALA   +4 more
doaj   +1 more source