Results 11 to 20 of about 25,228 (245)

The clinical relevance of sole loss of chromosome Y in myeloid neoplasms [PDF]

Blood Cancer Journal
Sandra Huber, Stephan Hutter, Manja Meggendorfer, Christian Pohlkamp, Torsten Haferlach, Isolde Summerer   +5 more
doaj   +2 more sources

Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases

Haematologica, 2012
We analyzed 636 patients with diverse myeloproliferative neoplasms or myelodysplastic/myeloproliferative neoplasms for mutations of the Casitas B-cell lymphoma gene (CBLmut) in exons 8 and 9 and performed correlations to other genetic alterations. CBLmut
Susanne Schnittger, Ulrike Bacher, Tamara Alpermann, Andreas Reiter, Madlen Ulke, Frank Dicker, Christiane Eder, Alexander Kohlmann, Vera Grossmann, Andreas Kowarsch, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach   +12 more
doaj   +1 more source

Molecular characterization of AML with RUNX1-RUNX1T1 at diagnosis and relapse reveals net loss of co-mutations

HemaSphere, 2019
. AML with RUNX1-RUNX1T1 fusion is a WHO entity with a favorable outcome following intensive chemotherapy. The absence of RUNX1-RUNX1T1 transcripts in remission defines complete molecular response and correlates with a superior survival.
Alexander Höllein, Niroshan Nadarajah, Manja Meggendorfer, Sabine Jeromin, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach   +6 more
doaj   +1 more source

Therapeutic targeting of MLL

Blood, 2009
AbstractTreatment of hematologic malignancies is evolving from a uniform approach to targeted therapies directed at the underlying molecular abnormalities of disease. The mixed lineage leukemia (MLL) proto-oncogene is a recurrent site of genetic rearrangements in acute leukemias; and since its discovery in 1992, many advances have been made in ...
Michaela, Liedtke, Michael L, Cleary
openaire   +3 more sources

Clinical application of whole transcriptome sequencing for the classification of patients with acute lymphoblastic leukemia

BMC Cancer, 2021
Background Considering the clinical and genetic characteristics, acute lymphoblastic leukemia (ALL) is a rather heterogeneous hematological neoplasm for which current standard diagnostics require various analyses encompassing morphology ...
Wencke Walter, Rabia Shahswar, Anna Stengel, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach   +6 more
doaj   +1 more source

Both SEPT2 and MLL are down-regulated in MLL-SEPT2therapy-related myeloid neoplasia [PDF]

BMC Cancer, 2009
Abstract Background A relevant role of septins in leukemogenesis has been uncovered by their involvement as fusion partners in MLL-related leukemia. Recently, we have established the MLL-SEPT2 gene fusion as the molecular abnormality subjacent to the translocation t(2;11)(q37;q23) in therapy-related acute myeloid ...
Cerveira, N., Santos, J., Bizarro, S., Costa, V., Ribeiro, F.R., Lisboa, S., Correia, C., Torres, L., Vieira, J., Snijder, S., Mariz, J.M., Norton, L., Mellink, C.H., Buijs, A., Teixeira, M.R.   +14 more
openaire   +6 more sources

In focus: MLL-rearranged leukemia [PDF]

Leukemia, 2013
The molecular mechanisms underlying oncogenesis in leukemias associated with rearrangement of the Mixed Lineage Leukemia (MLL) gene have received a considerable amount of attention over the last two decades. In this review we will focus on recent studies, published over the past year, that reveal new insights into the multi-protein complexes formed by ...
J, de Boer, V, Walf-Vorderwülbecke, O, Williams   +2 more
openaire   +2 more sources

Genomic characterization of mixed lineage leukemias [PDF]

World Cancer Research Journal, 2020
Developing new technologies and genomic techniques generate big data, which is very helpful to evaluate extensively hematologic malignancies. Besides wet lab results, such as gene and microRNA expression, methylation profile, next-generation sequencing ...
S. Dogan
doaj   +1 more source

MLL fusions: Pathways to leukemia [PDF]

Cancer Biology & Therapy, 2009
Human leukemias with chromosomal band 11q23 aberrations that disrupt the MLL/HRX/ALL-1 gene portend poor prognosis. MLL associated leukemias account for the majority of infant leukemia, approximately 10% of adult de novo leukemia and approximately 33% of therapy related acute leukemia with a balanced chromosome translocation.
Liu, Han, Cheng, Emily H.Y., Hsieh, James J.D.   +2 more
openaire   +3 more sources

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo [PDF]

Cancer Cell, 2015
Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on their interaction with menin, providing basis for therapeutic intervention.
Borkin, Dmitry, He, Shihan, Miao, Hongzhi, Kempinska, Katarzyna, Pollock, Jonathan, Chase, Jennifer, Purohit, Trupta, Malik, Bhavna, Zhao, Ting, Wang, Jingya, Wen, Bo, Zong, Hongliang, Jones, Morgan, Danet-Desnoyers, Gwenn, Guzman, Monica L., Talpaz, Moshe, Bixby, Dale L., Sun, Duxin, Hess, Jay L., Muntean, Andrew G., Maillard, Ivan, Cierpicki, Tomasz, Grembecka, Jolanta   +22 more
openaire   +2 more sources