Results 51 to 60 of about 7,144 (173)
Scientific Reports, 2020 Human plasma is a complex fluid, increasingly used for extracellular vesicle (EV) biomarker studies. Our aim was to find a simple EV-enrichment method for reliable quantification of EVs in plasma to be used as biomarker of disease.
Marija Holcar +7 more
doaj +1 more source
MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter
Frontiers in Pharmacology5-Lipoxygenase (5-LO), encoded by the gene ALOX5, is implicated in several pathologies. As key enzyme in leukotriene biosynthesis, 5-LO plays a central role in inflammatory diseases, but the 5-LO pathway has also been linked to development of certain ...
Marius Hyprath +4 more
doaj +1 more source
Radical scavenging activity of some natural tropolones by density functional theory
Bulletin of the Chemical Society of Ethiopia, 2017 The ground state neutral geometries of some natural tropolones, i.e. stipitatonic acid (AF1), stipitalide (AF2), stipitaldehydic acid (AF3) and methyl stipitate (AF4) have been optimized by using Density Functional Theory (DFT) at B3LYP/6-31G*, B3LYP/6 ...
A. G. Al-Sehemi +3 more
doaj +1 more source
Reward processing in children with affective dysregulation
JCPP Advances, EarlyView.Abstract Background Affective dysregulation (AD) in children is characterized by irritability, anger, and frequent intense temper outbursts. Considerable evidence implies altered processing of frustration about missed rewards, but few studies investigated the preceding and thus potentially predictive reward anticipation and initial delivery processing ...
Pascal‐M. Aggensteiner +11 more
wiley +1 more source
Mediation of Af4 protein function in the cerebellum by Siah proteins [PDF]
Proceedings of the National Academy of Sciences, 2004 We have established that the gene AF4 , which had long been recognized as disrupted in childhood leukemia, also plays a role in the CNS. Af4 is mutated in the robotic mouse that is characterized by ataxia and Purkinje cell loss.
Oliver, P +4 more
openaire +2 more sources
Small Methods, EarlyView.A fractionation‐free SAXS approach quantifies protein corona formation on silica nanoparticles under native conditions. By deconvoluting scattering from free and bound proteins, adsorbed mass is directly determined in simple and complex media. The method resolves adsorption regimes and thermodynamics, establishing non‐invasive, in situ characterization
Juliana T. T. Carvalho +6 more
wiley +1 more source
Viruses, 2018 Viruses protect their genomes by enclosing them into protein capsids that sometimes contain lipid bilayers that either reside above or below the protein layer.
Katri Eskelin, Minna M. Poranen
doaj +1 more source
Blocking SETD2 Enhances the Therapeutic Efficiency of Menin Inhibitor in MLL‐Fusion Leukemia
Cancer Science, EarlyView.Combined SETD2 and menin inhibitors make synergistic effects against MLL‐fusion leukemia; the combination therapy reduces the expression of target genes through blocking transcription elongation and initiation. ABSTRACT During transcriptional elongation, the histone methyltransferase SETD2 binds to RNA polymerase II and deposits trimethylation marks at
Anpei Li +10 more
wiley +1 more source
Molecules, 2022 Tomato sauce is a world famous food product. Despite standards regulating the production of tomato derivatives, the market suffers frpm fraud such as product adulteration, origin mislabelling and counterfeiting.
Alessandro Zappi +9 more
doaj +1 more source
European Journal of Pain, Volume 30, Issue 6, July 2026.ABSTRACT Background The identification of reliable neural signatures for pain remains a critical challenge in both clinical and experimental settings. While electroencephalography (EEG) provides a promising avenue for pain assessment, it remains unclear whether phase‐ or power‐based neural integration drives pain‐state discrimination.
Yiyuan Han +2 more
wiley +1 more source