Results 31 to 40 of about 20,267 (218)
Journal of Hematology & Oncology, 2019 Background Circular RNAs (circRNAs) represent a type of endogenous noncoding RNAs that are generated by back-splicing events and favor repetitive sequences.
Wei Huang +12 more
doaj +1 more source
Oncotarget, 2015 The human 5-lipoxygenase (5-LO), encoded by the ALOX5 gene, is the key enzyme in the formation of pro-inflammatory leukotrienes. ALOX5 gene transcription is strongly stimulated by calcitriol (1α, 25-dihydroxyvitamin D3) and TGFβ (transforming growth factor-β).
Ahmad, Khalil +6 more
openaire +4 more sources
Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells. [PDF]
PLoS ONE, 2012 BACKGROUND: The chromosomal translocation t(4;11)(q21;q23) is associated with high-risk acute lymphoblastic leukemia of infants. The resulting AF4•MLL oncoprotein becomes activated by Taspase1 hydrolysis and is considered to promote oncogenic ...
Carolin Bier +9 more
doaj +1 more source
iScience, 2023 Summary: MLL-rearranged (MLL-r) leukemias are among the leukemic subtypes with poorest survival, and treatment options have barely improved over the last decades.
Julie A. Johannessen +8 more
doaj +1 more source
Functional Dissociation of Mismatch Negativity From Late Discriminative Negativity Across the Adult Lifespan. [PDF]
Eur J NeurosciMismatch negativity (MMN) and late discriminative negativity (LDN) were reliably elicited by pitch contour deviants across adulthood (18–86 years). MMN amplitude declined with age and predicted subsequent auditory memory precision, whereas LDN amplitude remained largely stable and showed no relationship with memory performance.
Chow R, Bugos JA, Alain C, Rosenbaum RS.
europepmc +2 more sources
The robotic mouse: Unravelling the function of AF4 in the cerebellum
The Cerebellum, 2005 The devastating nature and lack of effective treatments associated with neurodegenerative diseases have stimulated a world-wide search for the elucidation of their molecular basis to which mouse models have made a major contribution. In combination with transgenic and knockout technologies, large-scale mouse mutagenesis is a powerful approach for the ...
Bitoun, E, Davies, K
openaire +2 more sources
Onset of word form recognition in English, Welsh, and English-Welsh bilingual infants [PDF]
, 2007 Children raised in the home as English or Welsh monolinguals or English–Welsh bilinguals were tested on untrained word form recognition using both behavioral and neurophysiological procedures.
Keren-Portnoy, Tamar +4 more
core +1 more source
Romanian Journal of Laboratory Medicine, 2013 Introducere. Pacienţii cu leucemie acuta limfoblastică (LAL) neonatală prezintă în mod frecvent, o tran- slocaţie particulară, t(4;ll)(q21;q23), care duce la fuziunea genei MLL (mixed lineage leukemia) de pe cromo- zomul 11 cu gena AF4 de pe cromozomul 4.
Ivanov Iuliu C. +7 more
doaj +1 more source
Frontiers in Sensors, 2022 Introduction: Gold nanoparticles (AuNPs) and their conjugates are used for many applications in the field of sensors. Literature lacks procedures able to separate, purify and characterize these species in native conditions without altering them while ...
Junjie Wang +9 more
doaj +1 more source
Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4–MLL Fusion Protein
EBioMedicine, 2015 We have recently demonstrated that Taspase1-mediated cleavage of the AF4–MLL oncoprotein results in the formation of a stable multiprotein complex which forms the key event for the onset of acute proB leukemia in mice.
Samaneh Sabiani +5 more
doaj +1 more source