Results 31 to 40 of about 7,144 (173)

Neuroprotective and anti-inflammatory effects of the flavonoid-enriched fraction AF4 in a mouse model of hypoxic-ischemic brain injury. [PDF]

PLoS ONE, 2012
We report here neuroprotective and anti-inflammatory effects of a flavonoid-enriched fraction isolated from the peel of Northern Spy apples (AF4) in a mouse of model of hypoxic-ischemic (HI) brain damage.
Paul G W Keddy, Kate Dunlop, Jordan Warford, Michel L Samson, Quinton R D Jones, H P Vasantha Rupasinghe, George S Robertson   +6 more
doaj   +1 more source

The Power of Field-Flow Fractionation in Characterization of Nanoparticles in Drug Delivery

Molecules, 2023
Asymmetric-flow field-flow fractionation (AF4) is a gentle, flexible, and powerful separation technique that is widely utilized for fractionating nanometer-sized analytes, which extend to many emerging nanocarriers for drug delivery, including lipid ...
Juan Bian, Nemal Gobalasingham, Anatolii Purchel, Jessica Lin   +3 more
doaj   +1 more source

Asymmetrical Flow Field-Flow Fractionation Coupled to ICP-MS for Characterization of Trace Metal Species in the Environment from Macromolecular to Nano-Assemblage Forms: Current Challenges for Quantification

CHIMIA, 2022
Asymmetrical flow field-flow fractionation (AF4) is a powerful technique employed for the separation of macromolecules, nanoparticles, and their assemblages according to their hydrodynamic behavior.
Isabelle A. M. Worms, Vera I. Slaveykova
doaj   +1 more source

Research on Multi-Energy Coordinated Intelligent Management Technology of Urban Power Grid Under the Environment of Energy Internet

Applied Sciences, 2019
Integrated energy systems (IES) are an important physical carrier of the energy Internet, which undertakes the tasks of energy conversion, distribution, and storage of electricity, heat and cold.
Xin Wang, Xiangyu Kong, Zhijun E, Fangyuan Sun, Changzhi Zhang   +4 more
doaj   +1 more source

Apple Peel Flavonoid Fraction 4 Suppresses Breast Cancer Cell Growth by Cytostatic and Cytotoxic Mechanisms

Molecules, 2019
Many dietary flavonoids possess anti-cancer activities. Here, the effect of apple peel flavonoid fraction 4 (AF4) on the growth of triple-negative (MDA-MB-231, MDA-MB-468), estrogen receptor-positive (MCF-7), and HER2-positive (SKBR3) breast cancer cells
Chao-Yu Loung, Wasundara Fernando, H.P. Vasantha Rupasinghe, David W. Hoskin   +3 more
doaj   +1 more source

Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair

Oncotarget, 2016
The most frequent rearrangement of the human MLL gene fuses MLL to AF4 resulting in high-risk infant B-cell acute lymphoblastic leukemia (B-ALL). MLL fusions are also hallmark oncogenic events in secondary acute myeloid leukemia. They are a direct consequence of mis-repaired DNA double strand breaks (DNA-DSBs) due to defects in the DNA damage response ...
Castaño, Julio, Herrero, Ana B., Bursen, Aldeheid, González, Federico, Marschalek, Rolf, Gutiérrez, Norma C., Menendez, Pablo   +6 more
openaire   +4 more sources

Asymmetrical Flow Field-Flow Fractionation Methods for Quantitative Determination and Size Characterization of Thiols and for Mercury Size Speciation Analysis in Organic Matter-Rich Natural Waters

Frontiers in Chemistry, 2022
Asymmetrical flow field-flow fractionation (AF4) efficiently separates various macromolecules and nano-components of natural waters according to their hydrodynamic sizes.
Isabelle A. M. Worms, Killian Kavanagh, Elodie Moulin, Nicole Regier, Vera I. Slaveykova   +4 more
doaj   +1 more source

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia

Nature Communications, 2023
Aberrant enhancer activation is a key mechanism driving oncogene expression in many cancers. While much is known about the regulation of larger chromosome domains in eukaryotes, the details of enhancer-promoter interactions remain poorly understood ...
Nicholas T. Crump, Alastair L. Smith, Laura Godfrey, Ana M. Dopico-Fernandez, Nicholas Denny, Joe R. Harman, Joseph C. Hamley, Nicole E. Jackson, Catherine Chahrour, Simone Riva, Siobhan Rice, Jaehoon Kim, Venkatesha Basrur, Damian Fermin, Kojo Elenitoba-Johnson, Robert G. Roeder, C. David Allis, Irene Roberts, Anindita Roy, Huimin Geng, James O. J. Davies, Thomas A. Milne   +21 more
doaj   +1 more source

Comparative analysis of the biological characteristics and mechanisms of azole resistance of clinical Aspergillus fumigatus strains

Frontiers in Microbiology, 2023
Aspergillus fumigatus is a common causative pathogen of aspergillosis. At present, triazole resistance of A. fumigatus poses an important challenge to human health globally. In this study, the biological characteristics and mechanisms of azole resistance
Meng Zeng, Meng Zeng, Xue Zhou, Chunhong Yang, Yanfei Liu, Jinping Zhang, Caiyan Xin, Gang Qin, Fangyan Liu, Zhangyong Song   +9 more
doaj   +1 more source

Functional Studies of MLL-AF4 and a Murinized pSer-variant thereof: MLL-AF4 Impairs the Ribosome Biosynthesis Pathway [PDF]

, 2021
Abstract Background: Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (1).
Anna Lena Siemund, Eric Kowarz, Rolf Marschalek   +2 more
openaire   +1 more source