A One‐Step Workflow for Size‐Based Separation of Extracellular Vesicles With Integrated Surface Marker Detection [PDF]
Journal of Extracellular BiologyExtracellular vesicles (EVs) are released by diverse cell types in biofluids and are increasingly studied in liquid biopsies as diagnostic and prognostic biomarkers for various diseases, including cancer.
Lien Lippens +13 more
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Clinical characteristics and prognostic analysis of different fusion gene abnormalities in childhood acute lymphoblastic leukaemia [PDF]
Frontiers in OncologyObjectiveThis study aimed to analyze the clinical features and prognostic significance of different fusion gene subtypes in pediatric patients with acute lymphoblastic leukaemia (ALL).MethodsClinical data from 132 childhood patients with ALL diagnosed ...
Rui Fan +9 more
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Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation. [PDF]
Adv Sci (Weinh)ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
Lundy DJ +8 more
europepmc +2 more sources
Bacillus-derived lipopeptides inhibit and eradicate Candida tropicalis Biofilms: An in vitro exploration [PDF]
BiofilmCandida tropicalis is a WHO-prioritised opportunistic fungal pathogen capable of causing superficial-to-systemic fungal infections and forming biofilms on both biotic and abiotic surfaces, such as tissues and medical implants.
Madhuri Madduri +2 more
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Stability of Am(Ⅲ) Colloid and Its Adsorption Behavior on Bentonite Colloids
He huaxue yu fangshe huaxue, 2022 The formation of Am(Ⅲ) colloid and its adsorption behaviors on bentonite colloid were investigated in Beishan 03 groundwater. A series of influencing factors, such as, pH, CO2 concentration in gas atmosphere, ionic strength and temperature, on colloidal ...
LIU Chen +6 more
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Pharmaceuticals, 2022 RNA molecules provide promising new possibilities for the prevention and treatment of viral infections and diseases. The rapid development of RNA biology and medicine requires advanced methods for the purification of RNA molecules, which allow fast and ...
Alesia A. Levanova +5 more
doaj +1 more source
RNA-binding proteins of KHDRBS and IGF2BP families control the oncogenic activity of MLL-AF4
Nature Communications, 2022 The establishment of a mouse model of MLL-AF4-induced leukaemia is a challenge as the introduction of fusion gene of human MLL-AF4 does not cause leukaemia in mice.
Hiroshi Okuda +7 more
doaj +1 more source
MLL-AF4 and a murinized pSer-variant thereof are turning on the nucleolar stress pathway
Cell & Bioscience, 2022 Background Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (Lin et ...
Anna Lena Siemund +3 more
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Frontiers in Molecular Biosciences, 2023 Background:Candida species are the main etiological agents for candidiasis, and Candida albicans are the most common infectious species. Candida species’ growing resistance to conventional therapies necessitates more research into novel antifungal agents.
Swetha Ramesh, Utpal Roy, Subhashis Roy
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Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia. [PDF]
PLoS ONE, 2015 MLL-rearranged acute lymphoblastic leukemia (ALL) in infants (
Marieke H van der Linden +10 more
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