Results 21 to 30 of about 7,188 (177)

Asymmetrical Flow Field-Flow Fractionation Methods for Quantitative Determination and Size Characterization of Thiols and for Mercury Size Speciation Analysis in Organic Matter-Rich Natural Waters

Frontiers in Chemistry, 2022
Asymmetrical flow field-flow fractionation (AF4) efficiently separates various macromolecules and nano-components of natural waters according to their hydrodynamic sizes.
Isabelle A. M. Worms, Killian Kavanagh, Elodie Moulin, Nicole Regier, Vera I. Slaveykova   +4 more
doaj   +1 more source

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia

Nature Communications, 2023
Aberrant enhancer activation is a key mechanism driving oncogene expression in many cancers. While much is known about the regulation of larger chromosome domains in eukaryotes, the details of enhancer-promoter interactions remain poorly understood ...
Nicholas T. Crump, Alastair L. Smith, Laura Godfrey, Ana M. Dopico-Fernandez, Nicholas Denny, Joe R. Harman, Joseph C. Hamley, Nicole E. Jackson, Catherine Chahrour, Simone Riva, Siobhan Rice, Jaehoon Kim, Venkatesha Basrur, Damian Fermin, Kojo Elenitoba-Johnson, Robert G. Roeder, C. David Allis, Irene Roberts, Anindita Roy, Huimin Geng, James O. J. Davies, Thomas A. Milne   +21 more
doaj   +1 more source

Comparative analysis of the biological characteristics and mechanisms of azole resistance of clinical Aspergillus fumigatus strains

Frontiers in Microbiology, 2023
Aspergillus fumigatus is a common causative pathogen of aspergillosis. At present, triazole resistance of A. fumigatus poses an important challenge to human health globally. In this study, the biological characteristics and mechanisms of azole resistance
Meng Zeng, Meng Zeng, Xue Zhou, Chunhong Yang, Yanfei Liu, Jinping Zhang, Caiyan Xin, Gang Qin, Fangyan Liu, Zhangyong Song   +9 more
doaj   +1 more source

circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression

Journal of Hematology & Oncology, 2019
Background Circular RNAs (circRNAs) represent a type of endogenous noncoding RNAs that are generated by back-splicing events and favor repetitive sequences.
Wei Huang, Ke Fang, Tian-Qi Chen, Zhan-Cheng Zeng, Yu-Meng Sun, Cai Han, Lin-Yu Sun, Zhen-Hua Chen, Qian-Qian Yang, Qi Pan, Xue-Qun Luo, Wen-Tao Wang, Yue-Qin Chen   +12 more
doaj   +1 more source

Frecuencia de los genes de fusión BCR-ABL1, E2A-PBX1, MLL-AF4, y TEL-AML1 con leucemia linfoblástica aguda de células B

Revista Peruana de Ciencias de la Salud, 2023
Objetivo. Describir la frecuencia de los genes de fusión BCR-ABL1, E2A-PBX1, MLL-AF4, y TEL-AML1 en pacientes con leucemia linfoblástica aguda de células B en el Instituto Nacional de Salud del Niño de San Borja, Lima (Perú). Métodos.
Francisco Sánchez-Pinto, Gioconda Manassero, Mónica Carola Correa Guerrero, Guillermo Frank Romero Guerra, Julissa Fuentes Vera   +4 more
doaj   +1 more source

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Cell Reports, 2017
Summary: Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic ...
Jon Kerry, Laura Godfrey, Emmanouela Repapi, Marta Tapia, Neil P. Blackledge, Helen Ma, Erica Ballabio, Sorcha O’Byrne, Frida Ponthan, Olaf Heidenreich, Anindita Roy, Irene Roberts, Marina Konopleva, Robert J. Klose, Huimin Geng, Thomas A. Milne   +15 more
doaj   +1 more source

AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3

Oncotarget, 2015
The human 5-lipoxygenase (5-LO), encoded by the ALOX5 gene, is the key enzyme in the formation of pro-inflammatory leukotrienes. ALOX5 gene transcription is strongly stimulated by calcitriol (1α, 25-dihydroxyvitamin D3) and TGFβ (transforming growth factor-β).
Ahmad, Khalil, Scholz, Bastian, Capelo, Ricardo, Schweighöfer, Ilona, Kahnt, Astrid Stefanie, Marschalek, Rolf, Steinhilber, Dieter   +6 more
openaire   +4 more sources

The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae

iScience, 2023
Summary: MLL-rearranged (MLL-r) leukemias are among the leukemic subtypes with poorest survival, and treatment options have barely improved over the last decades.
Julie A. Johannessen, Miriam Formica, Aina Louise C. Haukeland, Nora Rojahn Bråthen, Amani Al Outa, Miriam Aarsund, Marc Therrien, Jorrit M. Enserink, Helene Knævelsrud   +8 more
doaj   +1 more source

Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells. [PDF]

PLoS ONE, 2012
BACKGROUND: The chromosomal translocation t(4;11)(q21;q23) is associated with high-risk acute lymphoblastic leukemia of infants. The resulting AF4•MLL oncoprotein becomes activated by Taspase1 hydrolysis and is considered to promote oncogenic ...
Carolin Bier, Rouven Hecht, Lena Kunst, Sabine Scheiding, Désirée Wünsch, Dorothée Goesswein, Günter Schneider, Oliver H Krämer, Shirley K Knauer, Roland H Stauber   +9 more
doaj   +1 more source

Functional Studies of MLL-AF4 and a Murinized pSer-variant thereof: MLL-AF4 Impairs the Ribosome Biosynthesis Pathway [PDF]

, 2021
Abstract Background: Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (1).
Anna Lena Siemund, Eric Kowarz, Rolf Marschalek   +2 more
openaire   +1 more source