Results 11 to 20 of about 7,144 (173)

t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL [PDF]

Leukemia Research, 2011
The most frequent MLL-gene rearrangement found in leukemia is a reciprocal translocation with AF4 on chromosome 4 resulting in the formation of the MLL-AF4 and the AF4-MLL fusion genes. The oncogenic role of MLL-AF4 is documented but the significance of the reciprocal product - AF4-MLL in leukemia is less clear.
Ashish R Kumar, Qing Yao, Quanzhi Li
exaly   +3 more sources

Structural Profiling of Lipid Nanoparticles at Sub-10 nm Resolution via AF4 Coupled Online to SAXS and SANS. [PDF]

Small Methods
Dilution‐controlled AF4 coupled with SAXS and, for the first time, SANS enables high‐resolution characterization of non‐spherical lipid nanoparticles. Enhanced scattering contrast and D2O‐based measurements resolve particle features down to ∼5 nm and reveal shape distributions.
Bittrich E, Boye S, Van Niekerk Z, Stanvliet Z, Porfetye A, Herranz-Trillo F, Bolinsson H, Gaydarova S, Tzachev C, Martel A, Nilsson L, Schweins R, Lederer A.   +12 more
europepmc   +2 more sources

Interaction of AF4 wild-type and AF4·MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology? [PDF]

Oncogene, 2004
The human AF4 (ALL-1 fused gene on chromosome 4) gene (4q11) is recurrently involved in reciprocal translocations to the MLL (mixed lineage leukemia) gene (11q23), correlated with high-risk acute lymphoblastic leukemia (ALL) in infants and early childhood. The t(4;11) translocation is one of the most frequent MLL translocations known today. In general,
Soren Moritz, Rolf Marschalek, Marschalek Rolf   +2 more
exaly   +4 more sources

Concurrent MLL-AF4+ infant ALL in monozygotic twins: a case report [PDF]

Frontiers in Pediatrics
Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood, but it is relatively rare in infants. However, infant ALL exhibits distinct biological characteristics and an aggressive course, with a high proportion of cases involving MLL ...
Chenghui Li, Xin Tong, Jinfeng Yang, Hui Gao, Zhong Li   +4 more
doaj   +2 more sources

Cardio-renal protection and mechanisms of the antihypertensive activity of Alcalase-derived moth bean hydrolysate in DOCA-salt induced hypertensive Wistar rats [PDF]

Scientific Reports
Hypertension remains a major global health concern, often leading to severe cardiovascular and renal complications. In this study, we investigated the antihypertensive and cardiorenal protective effects of AF4, a bioactive Alcalase derived peptide ...
Nancy Goyal, Jitesh Singh Rathee, Sachin N. Hajare, S. Gautam   +3 more
doaj   +2 more sources

Alcalase–Flavourzyme Red Seaweed Hydrolysates as Antioxidants to Enhance Oxidative Stability of DHA Nanoemulsions [PDF]

Foods
This study evaluated Palmaria palmata hydrolysates produced using Alcalase® and Flavourzyme® at 1, 2, 3, 4, 5, and 10% (w/w biomass protein, corresponding to AF1-10), and their performance in oil-in-water nanoemulsions under iron-induced oxidation.
Sakhi Ghelichi, Behdad Shokrollahi Yancheshmeh, Seyed Hossein Helalat, Charlotte Jacobsen   +3 more
doaj   +2 more sources

AF4-to-SAXS: expanded characterization of nanoparticles and proteins at the P12 BioSAXS beamline [PDF]

Journal of Synchrotron Radiation
Biological small-angle X-ray scattering (SAXS) is a versatile and powerful technique for investigating the structural and biophysical properties of biologically and pharmaceutically relevant macromolecules and nanoparticles. SAXS offers detailed insights
Stefano Da Vela, Kim Bartels, Daniel Franke, Dymtro Soloviov, Tobias Gräwert, Dmitry Molodenskiy, Bastian Kolb, Christoph Wilhelmy, Roland Drexel, Florian Meier, Heinrich Haas, Peter Langguth, Melissa A. Graewert   +12 more
doaj   +2 more sources

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Cell Reports, 2017
Summary: Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic ...
Laura Godfrey, Emmanouela Repapi, Marta Tapia   +2 more
exaly   +3 more sources

Enhanced Contour-Deviant Mismatch Negativity and Mnemonic Representations in Older Musicians. [PDF]

Eur J Neurosci
Data showed enhanced MMN amplitudes in aging adult musicians compared with nonmusicians. Given that enhancements in MMN responses may be an indicator of preserved sensory processing in aging, music training may insulate age‐related decreases in sensory processing through preserved fidelity of encoding auditory information.
Bugos JA, Chow R, Mo S, Rosenbaum RS, Alain C.   +4 more
europepmc   +2 more sources

Understanding the Phenotypic Heterogeneity Within the Sporadic Creutzfeldt-Jakob Disease MV1 Subtype. [PDF]

Neuropathol Appl Neurobiol
We present the clinical, pathological and prion biophysical features of three atypical cases of the MV1 subtype of sporadic Creutzfeldt–Jakob disease (sCJD). We propose that these heterozygous cases exist on a spectrum ranging from MM1‐like to VV1‐like phenotypes and recommend that subtyping be performed at pH 6.9 to avoid missing atypical or mixed ...
Nemani SK, Cortez LM, Myskiw J, Cali I, Booth SA, Jansen GH, Sim VL.   +6 more
europepmc   +2 more sources