Results 11 to 20 of about 9,517 (210)
Oncotarget, 2015 The human 5-lipoxygenase (5-LO), encoded by the ALOX5 gene, is the key enzyme in the formation of pro-inflammatory leukotrienes. ALOX5 gene transcription is strongly stimulated by calcitriol (1α, 25-dihydroxyvitamin D3) and TGFβ (transforming growth factor-β).
Ahmad, Khalil +6 more
core +6 more sources
AF4 (ALL1 fused gene from chromosome 4) - AFF1 (AF4/FMR2 family, member 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on AFF1 (AF4/FMR2 family, member 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Marschalek, R, R Marschalek
openaire +3 more sources
The role of DOT1L in MLL-AF4 leukaemia [PDF]
, 2018 DOT1L is a methyltransferase which has been shown to methylate H3K79 (Ng et al. 2002; Feng et al. 2002; Lacoste et al. 2002). DOT1L and H3K79me have been shown to be involved in active transcription and in particular has been shown to be important for MLL-AF4 leukaemia, where high levels of H3K79me are found at MLL-AF4 gene targets (Krivtsov et al ...
Laura Godfrey, Godfrey, Laura
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Crosstalk between 14-3-3θ and AF4 enhances MLL-AF4 activity and promotes leukemia cell proliferation
Cellular Oncology, 2019 The t(4;11)(q21;q23) translocation characterizes a form of acute lymphoblastic leukemia with a poor prognosis. It results in a fusion gene encoding a chimeric transcription factor, MLL-AF4, that deregulates gene expression through a variety of still controversial mechanisms.
Fioretti T. +6 more
openaire +5 more sources
MLL-AF4 and a murinized pSer-variant thereof are turning on the nucleolar stress pathway
Cell & Bioscience, 2022 Background Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (Lin et ...
Anna Lena Siemund +3 more
doaj +2 more sources
MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter
Frontiers in Pharmacology5-Lipoxygenase (5-LO), encoded by the gene ALOX5, is implicated in several pathologies. As key enzyme in leukotriene biosynthesis, 5-LO plays a central role in inflammatory diseases, but the 5-LO pathway has also been linked to development of certain ...
Marius Hyprath +4 more
doaj +2 more sources
Mediation of Af4 protein function in the cerebellum by Siah proteins [PDF]
Proceedings of the National Academy of Sciences, 2004 We have established that the gene AF4 , which had long been recognized as disrupted in childhood leukemia, also plays a role in the CNS. Af4 is mutated in the robotic mouse that is characterized by ataxia and Purkinje cell loss.
Oliver, P +4 more
openaire +3 more sources
Synthesis and modification of octafluoro[2.2]paracyclophane (parylene AF4) [PDF]
Organic Chemistry Frontiers, 2014 Parylenes are a class of organic compounds which have gained significant attention due to their application as coatings in areas such as medical devices and electronics. This review highlights the development of synthetic pathways to Octafluoro[2.2]Paracyclophane, commonly referred to as parylene AF4.
Hicks, Craig +2 more
openaire +5 more sources
LAF4 (lymphoid nuclear protein related to AF4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on LAF4 (lymphoid nuclear protein related to AF4), with data on DNA, on the protein encoded, and where the gene is implicated.
von Bergh, ARM, ARM von Bergh
openaire +3 more sources
Pharmaceuticals, 2022 RNA molecules provide promising new possibilities for the prevention and treatment of viral infections and diseases. The rapid development of RNA biology and medicine requires advanced methods for the purification of RNA molecules, which allow fast and ...
Alesia A. Levanova +5 more
doaj +1 more source