Results 11 to 20 of about 7,188 (177)

RNA-binding proteins of KHDRBS and IGF2BP families control the oncogenic activity of MLL-AF4

Nature Communications, 2022
The establishment of a mouse model of MLL-AF4-induced leukaemia is a challenge as the introduction of fusion gene of human MLL-AF4 does not cause leukaemia in mice.
Hiroshi Okuda, Ryo Miyamoto, Satoshi Takahashi, Takeshi Kawamura, Juri Ichikawa, Ibuki Harada, Tomohiko Tamura, Akihiko Yokoyama   +7 more
doaj   +1 more source

MLL-AF4 and a murinized pSer-variant thereof are turning on the nucleolar stress pathway

Cell & Bioscience, 2022
Background Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (Lin et ...
Anna Lena Siemund, Thomas Hanewald, Eric Kowarz, Rolf Marschalek   +3 more
doaj   +1 more source

The elucidation of the multimodal action of the investigational anti-Candida lipopeptide (AF4) lead from Bacillus subtilis

Frontiers in Molecular Biosciences, 2023
Background:Candida species are the main etiological agents for candidiasis, and Candida albicans are the most common infectious species. Candida species’ growing resistance to conventional therapies necessitates more research into novel antifungal agents.
Swetha Ramesh, Utpal Roy, Subhashis Roy
doaj   +1 more source

Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia. [PDF]

PLoS ONE, 2015
MLL-rearranged acute lymphoblastic leukemia (ALL) in infants (
Marieke H van der Linden, Lidija Seslija, Pauline Schneider, Emma M C Driessen, Patricia Garrido Castro, Dominique J P M Stumpel, Eddy van Roon, Jasper de Boer, Owen Williams, Rob Pieters, Ronald W Stam   +10 more
doaj   +1 more source

Neuroprotective and anti-inflammatory effects of the flavonoid-enriched fraction AF4 in a mouse model of hypoxic-ischemic brain injury. [PDF]

PLoS ONE, 2012
We report here neuroprotective and anti-inflammatory effects of a flavonoid-enriched fraction isolated from the peel of Northern Spy apples (AF4) in a mouse of model of hypoxic-ischemic (HI) brain damage.
Paul G W Keddy, Kate Dunlop, Jordan Warford, Michel L Samson, Quinton R D Jones, H P Vasantha Rupasinghe, George S Robertson   +6 more
doaj   +1 more source

The Power of Field-Flow Fractionation in Characterization of Nanoparticles in Drug Delivery

Molecules, 2023
Asymmetric-flow field-flow fractionation (AF4) is a gentle, flexible, and powerful separation technique that is widely utilized for fractionating nanometer-sized analytes, which extend to many emerging nanocarriers for drug delivery, including lipid ...
Juan Bian, Nemal Gobalasingham, Anatolii Purchel, Jessica Lin   +3 more
doaj   +1 more source

Research on Multi-Energy Coordinated Intelligent Management Technology of Urban Power Grid Under the Environment of Energy Internet

Applied Sciences, 2019
Integrated energy systems (IES) are an important physical carrier of the energy Internet, which undertakes the tasks of energy conversion, distribution, and storage of electricity, heat and cold.
Xin Wang, Xiangyu Kong, Zhijun E, Fangyuan Sun, Changzhi Zhang   +4 more
doaj   +1 more source

Asymmetrical Flow Field-Flow Fractionation Coupled to ICP-MS for Characterization of Trace Metal Species in the Environment from Macromolecular to Nano-Assemblage Forms: Current Challenges for Quantification

CHIMIA, 2022
Asymmetrical flow field-flow fractionation (AF4) is a powerful technique employed for the separation of macromolecules, nanoparticles, and their assemblages according to their hydrodynamic behavior.
Isabelle A. M. Worms, Vera I. Slaveykova
doaj   +1 more source

Apple Peel Flavonoid Fraction 4 Suppresses Breast Cancer Cell Growth by Cytostatic and Cytotoxic Mechanisms

Molecules, 2019
Many dietary flavonoids possess anti-cancer activities. Here, the effect of apple peel flavonoid fraction 4 (AF4) on the growth of triple-negative (MDA-MB-231, MDA-MB-468), estrogen receptor-positive (MCF-7), and HER2-positive (SKBR3) breast cancer cells
Chao-Yu Loung, Wasundara Fernando, H.P. Vasantha Rupasinghe, David W. Hoskin   +3 more
doaj   +1 more source

Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair

Oncotarget, 2016
The most frequent rearrangement of the human MLL gene fuses MLL to AF4 resulting in high-risk infant B-cell acute lymphoblastic leukemia (B-ALL). MLL fusions are also hallmark oncogenic events in secondary acute myeloid leukemia. They are a direct consequence of mis-repaired DNA double strand breaks (DNA-DSBs) due to defects in the DNA damage response ...
Castaño, Julio, Herrero, Ana B., Bursen, Aldeheid, González, Federico, Marschalek, Rolf, Gutiérrez, Norma C., Menendez, Pablo   +6 more
openaire   +4 more sources