Results 71 to 80 of about 737,809 (280)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Field Guide [PDF]

, 2011
Abstract As part of the recent conference on the sedimentary geology of Mars, this guide was put together to find the best local analogies to what might be expected as Martian sedimentary deposits.
openaire   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A Field Guide to Optimizing Peptoid Synthesis. [PDF]

ACS Polym Au, 2022
Clapperton AM, Babi J, Tran H.
europepmc   +1 more source

Equilibrium electrons in free-electron lasers with a 3D helical wiggler and a guide magnetic field: Nonlinear simulations

Physical Review Special Topics. Accelerators and Beams, 2012
Nonlinear simulations are devoted to the comparative study of the equilibrium electrons’ motion and stability in the combination of a three-dimensional helical wiggler and a positive or reversed guide magnetic field, where effects of the self-field, off ...
Xiao-Li Huang, Shi-Jian Wang, Yong-Gen Xu, Shi-Chang Zhang   +3 more
doaj   +1 more source

A Field Guide to Ethics in Mathematics

Notices of the American Mathematical Society
10 pages, 1 figure. This article is a preliminary version of an article that will be published in the Notices of the AMS.
Chiodo, Maurice, Müller, Dennis
openaire   +3 more sources

MailScanner: A User Guide And Training Manual

, 2004
A guide to installing and using MailScanner, and a complete training manual describing its operation and use in fine ...
Field, Jules
core  

Field Guide to Researching Employment and Industrial Relations

The field of employment and industrial relations explores a myriad of complex topics, themes and phenomena, and this book provides a guide for researching this fascinating area. Investigating micro-, meso-, macro- and cross-national forms of analysis, it
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core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A field guide to Aurora kinase inhibitors: an oocyte perspective. [PDF]

Reproduction, 2022
Blengini CS, Ik Jung G, Aboelenain M, Schindler K.   +3 more
europepmc   +1 more source