Results 81 to 90 of about 737,809 (280)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Magnetic Field Analysis of Plasma Guide in Galathea Trimyx

open access: yesMATEC Web of Conferences, 2016
You Galathea Trimyx is a kind of small size, multipole magnetic confinement devices in controlled thermonuclear fusion. Plasma guide is one of important part in Galathea Trimyx which is responsible for transporting fast and slow plasma bunches ejected ...
Jin Xianji, Tong Weiming, Zhou Tianyi
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Creating AI Art Responsibly: A Field Guide for Artists

open access: yesDiseña, 2021
Machine learning tools for generating synthetic media enable creative expression, but they can also result in content that misleads and causes harm. The Responsible AI Art Field Guide offers a starting point for designers, artists, and other makers on ...
Claire Leibowicz   +2 more
doaj  

Billiken Field Hockey 1998 Media Guide

open access: yes, 2014
Media Guide of the 1998 Season of the Saint Louis University Women's Field Hockey ...
St. Louis University
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

Billiken Field Hockey 1997 Media Guide

open access: yes, 2014
Media Guide of the 1997 Season of the Saint Louis University Women's Field Hockey ...
St. Louis University
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

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