Results 51 to 60 of about 5,849,471 (294)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Pair density wave at high magnetic fields in cuprates with charge and spin orders

Nature Communications, 2020
Among the exotic phases in underdoped cuprates, the evidence of a pair density wave (PDW) remains inconclusive. Here, Shi et al. report transport signatures consistent with the presence of PDW pairing correlations that compete with uniform ...
Zhenzhong Shi, P. G. Baity, J. Terzic, T. Sasagawa, Dragana Popović   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

π–π Conjugated Bonds Stacking/Scattering for Switchable Lubrication in Supramolecular Hydrogel

Advanced Science
Existing polymer materials often lack the ability to dynamically adjust lubrication in response to external stimuli. This gap in adaptable lubrication technology limits their application in advanced systems such as intelligent motion devices and soft ...
Shuhang Deng, Shijia He, Guilong Yan, Li Wang, Zhenyu Li, Jingyu Chen, Jingjuan Lai, Dong Li, Dong Xiang, Chunxia Zhao, Hui Li, Xuezhong Zhang, Han Li, Xungai Wang, Yuanpeng Wu   +14 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Microstructure and properties of the welding heat-affected zone in CoCrNi medium-entropy alloy

Journal of Materials Research and Technology
To analyze the microstructure and mechanical properties of different regions for the welding heat-affected zone (HAZ) of CoCrNi medium-entropy alloy (MEA), the thermal simulations were conducted at peak temperatures of 800 °C, 1000 °C, and 1200 °C to ...
Xinzhe Liu, Yong Zhou, Hui Dong, Liang Sun, Yang Gao, Pengju Zhang   +5 more
doaj   +1 more source

IS THE ELECTROMAGNETIC FIELD MATERIAL?

, 2022
Abstract The point of view is substantiated, according to which the electromagnetic field in free space is not a kind of matter, but only one of the measures of the stress state of the ether, which is due to the inhomogeneous distribution of matter in it with its inherent charges and currents.
openaire   +1 more source

A theory for magnetic-field effects of nonmagnetic organic semiconducting materials

, 2010
A universal mechanism for strong magnetic-field effects of nonmagnetic organic semiconductors is presented. A weak magnetic field (less than hundreds mT) can substantially change the charge carrier hopping coefficient between two neighboring organic ...
Francis T. L., Landau L. D., S. J. Xie, Schwob H. P., Shklovskii B. I., Wang X. R., Wang X. R., X. R. Wang   +7 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source