Results 71 to 80 of about 2,215,078 (318)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
In the Magnetic Fields of Materialism and Anthropology [PDF]
Anthropology & Materialism, 2013 For all those points in which, despite our most fundamental and concrete agreement in other matters, I differ from you could be summed up and characterized as an anthropological materialism that I cannot accept. It is as if for you the human body represents the measure of all concreteness.
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
High-Capacityand Reversible Hydrogen Storage in an Intrinsic Li3B2N2 Monolayer
NanomaterialsHydrogen is widely considered a promising clean energy carrier because of its high energy density and environmental benignity, yet the development of safe and reversible hydrogen storage materials remains a major challenge.
Haichuan Yu +5 more
doaj +1 more source
Influence of the intermediate material on the singular stress field in tri-material junctions [PDF]
, 2004 According to the mathematical formalism of the eigenfunction expansion method, the problem of stress-singularities arising from multi-material junctions is addressed.
M. PAGGI +4 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Quantum Hall effect in a CVD-grown oxide
Nature CommunicationsTwo-dimensional (2D) electron systems are promising for investigating correlated quantum phenomena. In particular, 2D oxides provide a platform that can host various quantum phases such as quantized Hall effect, superconductivity, or magnetism.
Oleksandr Zheliuk +12 more
doaj +1 more source
, 1916 Andrew Field (1938- ) is a scholar, translator, and author, who has published translations of Russian literature, critical studies, biographies, fiction, essays, and travel articles. He holds degrees from Columbia University as well as a Ph.D.
Field, Andrew
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MagnetochemistryThe development of novel synthesis and assembly strategies is critical to achieving a ferromagnetic organic semiconductor with high Curie temperature. In this study, we report a high magnetic field (HMF)-modified solvothermal approach for the reduction ...
Han Zhou +5 more
doaj +1 more source