Results 91 to 100 of about 10,222,885 (316)

Precision medicine and digital phenotyping: Digital medicine's way from more data to better health

Big Data & Society, 2021
Precision medicine and digital phenotyping are two prominent data-based approaches within digital medicine. While precision medicine historically used primarily genetic data to find targeted treatment options, digital phenotyping relies on the usage of ...
Renate Baumgartner
doaj   +1 more source

Monitoring drought responses of barley genotypes with semi-robotic phenotyping platform and association analysis between recorded traits and allelic variants of some stress genes [PDF]

, 2013
Genetic improvement of complex traits such as drought adaptation can be advanced by the combination of genomic and phenomic approaches. Semi-robotic phenotyping platform was used for computer-controlled watering, digital and thermal imaging of barley ...
Cseri, András, Dudits, Dénes, Pauk, János, Sass, László, Törjék, Ottó, Vass, Imre   +5 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Field phenotyping of plant height in an upland rice field in Laos using low-cost small unmanned aerial vehicles (UAVs)

, 2020
Plant height (PH) is an important agronomical parameter to assess the growth status in upland rice fields. Recently, field-based phenotyping using unmanned aerial vehicles (UAVs) has received increasing attention as a cost-effective, well-suited sensing ...
K. Kawamura, Hidetoshi Asai, T. Yasuda, Phanthasin Khanthavong, Pheunphit Soisouvanh, Sengthong Phongchanmixay   +5 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Quinoa Phenotyping Methodologies: An International Consensus

Plants, 2021
Quinoa is a crop originating in the Andes but grown more widely and with the genetic potential for significant further expansion. Due to the phenotypic plasticity of quinoa, varieties need to be assessed across years and multiple locations.
Clara S. Stanschewski, Elodie Rey, Gabriele Fiene, Evan B. Craine, Gordon Wellman, Vanessa J. Melino, Dilan S. R. Patiranage, Kasper Johansen, Sandra M. Schmöckel, Daniel Bertero, Helena Oakey, Carla Colque-Little, Irfan Afzal, Sebastian Raubach, Nathan Miller, Jared Streich, Daniel Buchvaldt Amby, Nazgol Emrani, Mark Warmington, Magdi A. A. Mousa, David Wu, Daniel Jacobson, Christian Andreasen, Christian Jung, Kevin Murphy, Didier Bazile, Mark Tester, on behalf of the Quinoa Phenotyping Consortium   +27 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Implementing a Portable Clinical NLP System with a Common Data Model - a Lisp Perspective

, 2018
This paper presents a Lisp architecture for a portable NLP system, termed LAPNLP, for processing clinical notes. LAPNLP integrates multiple standard, customized and in-house developed NLP tools.
Luo, Yuan, Szolovits, Peter
core   +1 more source