Results 91 to 100 of about 59,219 (244)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

GLiMPSe: A low-cost, high-throughput and accurate field phenotyping system for maize architectural traits

Smart Agricultural Technology
Maize phenotyping remains a major bottleneck in genetic analysis and breeding. Despite advances in drones, field robots, and gantry phenotyping systems, ultra-affordable, high-throughput, field-based maize phenotyping at single-plant resolution is still ...
Shaoqi Fan, Guoji Li, Shouzhen Teng, Revocatus Bahitwa, Mingchi Xu, Yiheng Qian, Qiuying Yu, Jinghong Shao, Xiaoran Chen, Hai Wang   +9 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Response to oxalic acid: an important supplement screening against stem rot resistance in groundnut (Arachis hypogaea L.)

BMC Plant Biology
Background Stem rot, caused by the soil-borne pathogen Sclerotium rolfsii, pose a serious challenge in the groundnut (Arachis hypogaea L) cultivation. Although this disease is widespread globally but had most adverse impact in groundnut growing regions ...
H. V. Veerendrakumar, Bangaru Kiranmayee, R. P. Vasanthi, A. R. Nirmal Kumar, Manish K. Pandey, Hari Kishan Sudini   +5 more
doaj   +1 more source

Review of Crop Phenotyping in Field Plot Experiments Using UAV-Mounted Sensors and Algorithms

Drones
The phenotyping of field crops quantifies a plant’s structural and physiological characteristics to facilitate crop breeding. High-throughput unmanned aerial vehicle (UAV)-based remote sensing platforms have been extensively researched as replacements ...
Takashi Sonam Tashi Tanaka, Sheng Wang, Johannes Ravn Jørgensen, Marco Gentili, Armelle Zaragüeta Vidal, Anders Krogh Mortensen, Bharat Sharma Acharya, Brittany Deanna Beck, René Gislum   +8 more
doaj   +1 more source

Field phenotyping of ten wheat cultivars under elevated CO₂ shows seasonal differences in chlorophyll fluorescence, plant height and vegetation indices. [PDF]

Front Plant Sci, 2023
Knopf O, Castro A, Bendig J, Pude R, Kleist E, Poorter H, Rascher U, Muller O.   +7 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

In-Field Nondestructive Detection of Nitrogen Status on ‘Yotsuboshi’ Strawberry Using Deep Learning Algorithm

Sensors
Nitrogen (N) management is critical for optimizing growth and fruit quality in open-field strawberry cultivation, demanding advanced technological solutions for reliable nutrient assessment.
Bryan V. Apacionado, Tofael Ahamed
doaj   +1 more source