Results 61 to 70 of about 428,890 (310)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Analysis of Red and Far-Red Sun-Induced Chlorophyll Fluorescence and Their Ratio in Different Canopies Based on Observed and Modeled Data

Remote Sensing, 2016
Sun-induced canopy chlorophyll fluorescence in both the red (FR) and far-red (FFR) regions was estimated across a range of temporal scales and a range of species from different plant functional types using high resolution radiance spectra collected on ...
Micol Rossini, Michele Meroni, Marco Celesti, Sergio Cogliati, Tommaso Julitta, Cinzia Panigada, Uwe Rascher, Christiaan van der Tol, Roberto Colombo   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Illumination-Independent Reflectance Information Acquirement for Leaf Water Potential Measurement on the Example of Satsuma Mandarin

International Journal of Horticultural Science, 2003
Mandarin fruit sugar content can be increased when subjecting the satsuma mandarin tree (Citrus unshiu MARC. var. satsuma) to moderate water stress by mulching during the period of active sugar accumulation, thereby fruit quality improvement can be ...
J. Kriston-Vizi, M. Umeda, K. Miyamoto, A. Ferenczy   +3 more
doaj   +1 more source

Multi-field frequency modulation spectroscopy

Optics Express, 2008
We Study a modification of classical FM spectroscopy in the cases where several electromagnetic fields are FM modulated, each in a different manner. This complex spectrum scans a multi-photon resonant atomic medium with the output detected by a phase-sensitive scheme. The demodulated output signal reveals the spectroscopic features of the probed medium.
Ido, Ben-Aroya, Matan, Kahanov, Gadi, Eisenstein   +2 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Control of morphology and formation of highly geometrically confined magnetic skyrmions

Nature Communications, 2017
Proposals for skyrmion-based high-density memory devices require an understanding of the formation and shape of skyrmions in confined geometries. Here, the authors use electron holography to image magnetic textures in FeGe nanostripes and explore the ...
Chiming Jin, Zi-An Li, András Kovács, Jan Caron, Fengshan Zheng, Filipp N. Rybakov, Nikolai S. Kiselev, Haifeng Du, Stefan Blügel, Mingliang Tian, Yuheng Zhang, Michael Farle, Rafal E Dunin-Borkowski   +12 more
doaj   +1 more source

Mapping Arctic Tundra Vegetation Communities Using Field Spectroscopy and Multispectral Satellite Data in North Alaska, USA

Remote Sensing, 2016
The Arctic is currently undergoing intense changes in climate; vegetation composition and productivity are expected to respond to such changes. To understand the impacts of climate change on the function of Arctic tundra ecosystems within the global ...
Scott J. Davidson, Maria J. Santos, Victoria L. Sloan, Jennifer D. Watts, Gareth K. Phoenix, Walter C. Oechel, Donatella Zona   +6 more
doaj   +1 more source

Hyperspectral Measurements Enable Pre-Symptomatic Detection and Differentiation of Contrasting Physiological Effects of Late Blight and Early Blight in Potato

Remote Sensing, 2020
In-vivo foliar spectroscopy, also known as contact hyperspectral reflectance, enables rapid and non-destructive characterization of plant physiological status.
Kaitlin M. Gold, Philip A. Townsend, Adam Chlus, Ittai Herrmann, John J. Couture, Eric R. Larson, Amanda J. Gevens   +6 more
doaj   +1 more source

The role of level anti-crossings in nuclear spin hyperpolarization

, 2014
Nuclear spin hyperpolarization is an important resource for increasing the sensitivity of NMR spectroscopy and MRI. Signal enhancements can be as large as 3-4 orders of magnitude.
NMR Spectroscopy, Kaptein, R, Sub NMR Spectroscopy, Pravdivtsev, Andrey N., Vieth, Hans Martin, Ivanov, Konstantin L., Yurkovskaya, Alexandra V.   +6 more
core   +1 more source