Results 91 to 100 of about 572,960 (261)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A landscape-scale field survey demonstrates the role of wheat volunteers as a local and diversified source of leaf rust inoculum. [PDF]

Sci Rep, 2023
Boixel AL, Goyeau H, Berder J, Moinard J, Suffert F, Soubeyrand S, Sache I, Vidal T.   +7 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

CMRD-Net: a deep learning-based Cnaphalocrocis medinalis damage symptom rotated detection framework for in-field survey. [PDF]

Front Plant Sci, 2023
Chen T, Wang R, Du J, Chen H, Zhang J, Dong W, Zhang M.   +6 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Characteristics Study of Reservoirs Pores and Mineral Compositions for Black Shale, Northern Guizhou, by Using SEM and X-ray EDS

Yankuang ceshi, 2014
Shale reservoir research has become a focus in the study of shale gas, and the special structure feature of shale development at the nano/micro level pore size. Guizhou is one of the shale gas test pilot areas in our country.
WANG Kun-yang, DU Gu, YANG Yu-jie, DONG Shi-tao, YU Xiao-lin, GUO Jian-wei   +5 more
doaj   +2 more sources

Chemistry, Growth, and Fate of the Unique, Short‐Lived (2019–2020) Water Lake at the Summit of Kīlauea Volcano, Hawaii

Geochemistry, Geophysics, Geosystems
Less than a year after the 2018 Kīlauea caldera collapse and eruption, water appeared in newly deepened Halemaʻumaʻu crater. The lake—unprecedented in the written record—grew to a depth of ∼50 m before lava from the December 2020 eruption boiled it away.
P. A. Nadeau, S. Hurwitz, S. Peek, A. H. Lerner, E. F. Younger, M. R. Patrick, D. E. Damby, R. B. McCleskey, P. J. Kelly   +8 more
doaj   +1 more source

Precise and Efficient Pointing Control of a 2.5-m-Wide Field Survey Telescope Using ADRC and Nonlinear Disturbance Observer. [PDF]

Sensors (Basel), 2023
Liu Y, Deng Y, Li H, Wang J, Wang D.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

ToLCNDV-ES infection in tomato is enhanced by TYLCV: Evidence from field survey and agroinoculation. [PDF]

Front Microbiol, 2022
Vo TTB, Troiano E, Lal A, Hoang PT, Kil EJ, Lee S, Parrella G.   +6 more
europepmc   +1 more source