Results 51 to 60 of about 572,960 (261)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Radiogenic Strontium‐ and Uranium‐Isotope Tracers of Water‐Rock Interactions and Hydrothermal Flow in the Upper Geyser Basin, Yellowstone Plateau Volcanic Field, USA

Geochemistry, Geophysics, Geosystems
Natural radiogenic isotopes (primarily 87Sr/86Sr) from hot springs in the Upper Geyser Basin of the Yellowstone Plateau volcanic field and associated rocks were used to evaluate groundwater flow patterns, water‐rock reactions, and the extent of mixing ...
James B. Paces, Shaul Hurwitz, Lauren N. Harrison, Jacob B. Lowenstern, R. Blaine McCleskey   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

GRAPES: Earthquake Early Warning by Passing Seismic Vectors Through the Grapevine

Geophysical Research Letters
Estimating an earthquake's magnitude and location may not be necessary to predict shaking in real time; instead, wavefield‐based approaches predict shaking with few assumptions about the seismic source.
T. Clements, E. S. Cochran, A. Baltay, S. E. Minson, C. E. Yoon   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

TheXMM‐NewtonWide‐Field Survey in the COSMOS Field. I. Survey Description

The Astrophysical Journal Supplement Series, 2007
We present the first set of XMM-Newton EPIC observations in the 2 square degree COSMOS field. The strength of the COSMOS project is the unprecedented combination of a large solid angle and sensitivity over the whole multiwavelength spectrum. The XMM-Newton observations are very efficient in localizing and identifying active galactic nuclei (AGN) and ...
G. Hasinger, N. Cappelluti, H. Brunner, BRUSA, MARCELLA, A. Comastri, M. Elvis, A. Finoguenov, F. Fiore, A. Franceschini, R. Gilli, R. E. Griffiths, I. Lehmann, V. Mainieri, G. Matt, I. Matute, T. Miyaji, S. Molendi, S. Paltani, D. B. Sanders, N. Scoville, L. Tresse, C. M. Urry, P. Vettolani, G. Zamorani   +23 more
openaire   +7 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Astrometry in Wide‐Field Surveys

Publications of the Astronomical Society of the Pacific, 2006
We present a robust and fast algorithm for performing astrometry and source cross-identification on two dimensional point lists, such as between a catalogue and an astronomical image, or between two images. The method is based on minimal assumptions: the lists can be rotated, magnified and inverted with respect to each other in an arbitrary way.
Pal, Andras, Bakos, Gaspar
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source