Results 71 to 80 of about 2,489,717 (313)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Field Testing, Traction Dynamometer

, 1939
Implement field tests. A traction dynamometer from the early test days was used in those tests. It is not clear what was tested, but it appears to be at Hoffman Estates. The tractor used here was a Minneapolis Moline.
Lester F. Larsen Tractor Test and Power Museum
core  

Verfahrensdokumentation für STARS-D: Statistic Anxiety Rating Scale - deutsche Fassung

, 2015
Die STARS-D eignet sich für Forschungszwecke, um die Angst von Studierenden in Bezug auf Statistik zu erfassen. Es kann auch für die Beratung von Studierenden eingesetzt werden, zum Beispiel bei Lern- und Studienschwierigkeiten.
Paechter, M., Macher, D., Ruggeri, K., Papousek, I.   +3 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Deep Multi-Layer Perception Based Terrain Classification for Planetary Exploration Rovers

Sensors, 2019
Accurate classification and identification of the detected terrain is the basis for the long-distance patrol mission of the planetary rover. But terrain measurement based on vision and radar is subject to conditions such as light changes and dust storms.
Chengchao Bai, Jifeng Guo, Linli Guo, Junlin Song   +3 more
doaj   +1 more source

FIELD TESTS OF ASTROMETRIC SUBSYSTEM

Geodesy and cartography, 2016
The paper presents results of astrometric subsystem’s functionality tests for space object laser ranging and astrometric position determination device, which is under construction in the Institute of Geodesy and Geoinformatics (GGI) of the University of Latvia.
Zariņš, Ansis, Haritonova, Diāna, Rubans, Augusts, Silabriedis, Gunārs, Zvirgzds, Jānis   +4 more
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Experimental and Numerical Research on p-y Curve of Offshore Photovoltaic Pile Foundations on Sandy Soil Foundation

Journal of Marine Science and Engineering
While methods like cyclic triaxial testing and p-y model updating theory exist in geotechnical and offshore wind engineering, they have not been systematically applied to solve the specific deformation problems of offshore PV piles.
Sai Fu, Hongxin Chen, Guo-er Lv, Xianlin Jia, Xibin Li   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Corrosion behavior of experimental nickel-bearing carbon steels evaluated using field and electrochemical tests

REM: International Engineering Journal
The aim of this study was to evaluate the corrosion resistance of Ni-bearing carbon steels used in outdoor structures from short-term experimental techniques and compare with the long-term field test data.
Vanessa Lins, Edelize Angelica Gomes, Cíntia Gonçalves Costa, Maria das Mercês Reis Castro, Rogerio Augusto Carneiro   +4 more
doaj   +1 more source