Results 81 to 90 of about 7,278,095 (302)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Field Tests and the Numerical Analysis of a Pile-Net Composite Foundation for an Intelligent Connected Motor-Racing Circuit

Buildings
In response to the problem of significant post-construction settlement that may occur in a motor racing circuit (MRC), two representative composite foundation testing areas, PHC pile (pre-tensioned spun high-strength concrete pile) and CFG pile (cement ...
Xiaonan Wang, Qitao Pei
doaj   +1 more source

Design and Application of New Running Tool

Shiyou jixie, 2021
In response to the failure of machinery or hydraulic release during downhole operation in oil and gas fields, no stand-by solutions are available and various running tools are lack of applicability.
Hao Zhouzheng, Cheng Zhong, Zhang Ying, Liu Yuming, Chen Liwei, Chai Xiwei   +5 more
doaj  

FSA field test report, 1980 - 1982 [PDF]

Photovoltaic modules made of new and developing materials were tested in a continuing study of weatherability, compatibility, and corrosion protection.
Amy, J. A., Frickland, P. O., Grimmett, C. A., Maxwell, H. G., Repar, J.   +4 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Development and Field Testing of a Wireless Data Relay System for Amphibious Drones

Drones
Amphibious (air and water) drones, capable of both aerial and aquatic operations, have the potential to provide valuable drone applications in aquatic environments. However, the limited range of wireless data transmission caused by the low antenna height
Atsushi Suetsugu, Hirokazu Madokoro, Takeshi Nagayoshi, Takero Kikuchi, Shunsuke Watanabe, Makoto Inoue, Makoto Yoshida, Hitoshi Osawa, Nobumitsu Kurisawa, Osamu Kiguchi   +9 more
doaj   +1 more source

Erosion-resisting Characteristic Study of Throttle Valve in High-pressure Liquid-solid Flow

Shiyou jixie, 2022
The throttle valve with reliable performance parameters plays a key role in the reasonable control of bottom hole pressure in high pressure, high sulfur content and high yield wells, and it is one of the decisive factors for the successful establishment ...
Li Qiandeng, Guan Zhichuan, Fan Chaobin, Liu Minggang, Wu Desong   +4 more
doaj  

Response of Diabrotica speciosa (Coleoptera: Chrysomelidae) to 1,4-dimethoxybenzene and analogs in common bean crop

Brazilian Archives of Biology and Technology, 2009
Several synthetic and commercial analogs of 1,4-dimethoxybenzene, a kairomone of Diabrotica speciosa, along with other compounds already shown to be attractive to other species of Diabrotica, were tested as attractant to D. speciosa.
Francisco de Assis Marques, Edison Perevalo Wendler, Alexandra Macedo, Celso Luiz Wosch, Beatriz Helena Sales Maia, Adriana Yatie Mikami, Iara Cintra Arruda-Gatti, Aline Pissinati, Fábio Luiz Checchio Mingotte, Amilton Alves, Maurício Ursi Ventura   +10 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Transverse strength of railway tracks: part 3. Multiple scenarios test field

Fracture and Structural Integrity, 2014
In the present paper the design and construction choices of a test field for the ballast lateral resistance measurement, in order to produce data useful for the development of a numerical model able to simulate the service critical conditions of a ...
Antonio De Iorio, Francesco Penta, Giovanni Pio Pucillo, Vincenzo Rosiello, Stefano Lisi, Stefano Rossi, Mario Testa   +6 more
doaj