Results 81 to 90 of about 706,626 (288)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Odd dimensional nonlocal Liouville conformal field theories

Journal of High Energy Physics, 2022
We construct Euclidean Liouville conformal field theories in odd number of dimensions. The theories are nonlocal and non-unitary with a log-correlated Liouville field, a Q $$ \mathcal{Q} $$ -curvature background, and an exponential Liouville-type ...
Amitay C. Kislev, Tom Levy, Yaron Oz
doaj   +1 more source

Brane Content of Branes' States

, 2003
The problem of decomposition of unitary irreps of (super) tensorial (i.e. extended with tensorial charges) Poincar{\'e} algebra w.r.t. its different subalgebras is considered.
Abdel-Khalek, Baez, Bandos, Bandos, Bandos, Bars, Bars, Bars, Barut, de Azcarraga, Gauntlett, Gauntlett, Gunaydin, Gunaydin, Gunaydin, Kugo, Manvelyan, Manvelyan, Mkrtchyan, Mkrtchyan, Ruben Mkrtchyan, Townsend, Vasiliev, Wigner   +23 more
core   +2 more sources

Higher dimensional higher derivative φ⁴ theory [PDF]

, 2017
We construct several towers of scalar quantum field theories with an $O(N)$ symmetry which have higher derivative kinetic terms. The Lagrangians in each tower are connected by lying in the same universality class at the $d$-dimensional Wilson-Fisher ...
Gracey, JA, Simms, RM
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Effective field equation on m-brane embedded in n-dimensional bulk of Einstein and f(R) gravity

, 2015
We have derived effective gravitational field equations on a lower dimensional hypersurface (known as a brane), placed in a higher dimensional bulk spacetime for both Einstein and $f(\mathcal{R})$ gravity theories.
Chakraborty, Sumanta, SenGupta, Soumitra
core   +1 more source

Critical exponents from optimised renormalisation group flows [PDF]

, 2002
Within the exact renormalisation group, the scaling solutions for O(N) symmetric scalar field theories are studied to leading order in the derivative expansion. The Gaussian fixed point is examined for d>2 dimensions and arbitrary infrared regularisation.
Aoki, Bagnuls, Ball, Bergerhoff, Bergerhoff, Bergerhoff, Berges, Bohr, Bonanno, Comellas, Daniel F. Litim, Ellwanger, Ellwanger, Freire, Golner, Hasenfratz, Lauscher, Lauscher, Liao, Liao, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Margaritis, Mazza, Morris, Morris, Morris, Morris, Polchinski, Reuter, Reuter, Tetradis, Tetradis, Von Gersdorff, Wetterich, Wetterich, Zinn-Justin   +47 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Little Hierarchy in Universal Extra Dimensions [PDF]

, 2006
In the standard model in universal extra dimensions (UED) the mass of the Higgs field is driven to the cutoff of the higher-dimensional theory. This re-introduces a small hierarchy since the compactification scale 1/R should not be smaller than the weak ...
Alex G Dias, D.E. Kaplan, For reviews see M. Schmaltz, G. Burdman, Gustavo Burdman, M. Schmaltz, N. Arkani-Hamed, N. Arkani-Hamed, Particle Data Group, R. Barbieri, Z. Chacko, Z. Chacko   +11 more
core   +2 more sources