Results 61 to 70 of about 37,951 (270)

The 1-loop effective potential for the Standard Model in curved spacetime

open access: yesJournal of High Energy Physics, 2018
The renormalisation group improved Standard Model effective potential in an arbitrary curved spacetime is computed to one loop order in perturbation theory.
Tommi Markkanen   +3 more
doaj   +1 more source

Modular Hamiltonian of the scalar in the semi infinite line: dimensional reduction for spherically symmetric regions

open access: yesJournal of High Energy Physics, 2023
We focus our attention on the one dimensional scalar theories that result from dimensionally reducing the free scalar field theory in arbitrary d dimensions.
Marina Huerta, Guido van der Velde
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Finite volume form factors in integrable theories

open access: yesJournal of High Energy Physics
We develop a new method to calculate finite size corrections for form factors in two-dimensional integrable quantum field theories. We extract these corrections from the excited state expectation value of bilocal operators in the limit when the operators
Zoltan Bajnok   +3 more
doaj   +1 more source

Odd dimensional nonlocal Liouville conformal field theories

open access: yesJournal of High Energy Physics, 2022
We construct Euclidean Liouville conformal field theories in odd number of dimensions. The theories are nonlocal and non-unitary with a log-correlated Liouville field, a Q $$ \mathcal{Q} $$ -curvature background, and an exponential Liouville-type ...
Amitay C. Kislev, Tom Levy, Yaron Oz
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

On the Inherent Incompleteness of Scientific Theories [PDF]

open access: yes, 2004
We examine the question of whether scientific theories can ever be complete. For two closely related reasons, we will argue that they cannot. The first reason is the inability to determine what are “valid empirical observations”, a result that is based ...
Jolly Mathen, Mathen, Jolly
core  

Perils of Towers in the Swamp: Dark Dimensions and the Robustness of Effective Field Theories [PDF]

open access: yes, 2023
Recently there has been an interesting revival of the idea to use large extra dimensions to address the dark energy problem, exploiting the (true) observation that towers of states with masses split, by $M^2_N = f(N) m^2,$ with $f$ an unbounded function ...
Burgess, C. P., Quevedo, F.
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Consistency of gravitational effective field theories [PDF]

open access: yes
Quantum field theories are most pragmatically viewed as effective field theories, accurately describing physics within a finite range of energy or length scales.
Jaitly, Sumer
core   +1 more source

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