Results 51 to 60 of about 37,951 (270)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

An inverse mass expansion for the mutual information in free scalar QFT at finite temperature

Journal of High Energy Physics, 2020
We study the entanglement entropy and the mutual information in coupled harmonic systems at finite temperature. Interestingly, we find that the mutual information does not vanish at infinite temperature, but it rather reaches a specific finite value ...
Dimitrios Katsinis, Georgios Pastras
doaj   +1 more source

Comments on QCD3 and anomalies with fundamental and adjoint matter

Journal of High Energy Physics, 2022
’t Hooft anomaly matching is powerful for constraining the low energy phases of gauge theories. In 3d one common anomaly is the parity anomaly in a T-symmetric theory where one cannot gauge the global symmetry group without breaking the time-reversal ...
Nakarin Lohitsiri, Tin Sulejmanpasic
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Light scalars on cosmological backgrounds

Journal of High Energy Physics, 2018
We study the behaviour of a light quartically self-interacting scalar field ϕ on curved backgrounds that may be described with the cosmological equation state parameter w.
Tommi Markkanen
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Bootstrapping massive quantum field theories [PDF]

We propose a new non-perturbative method for studying UV complete unitary quantum field theories (QFTs) with a mass gap in general number of spacetime dimensions.
Penedones, Joao, Karateev, Denis, Kuhn, Simon   +2 more
core   +2 more sources

(Non)-Invertible Topology in Quantum Field Theory [PDF]

, 2023
This thesis aims to highlight aspects of mathematics and physics that arise in topological field theories. We will consider invertible and noninvertible topological theories.
Yu, Matthew
core  

Liouville theory: an introduction to rigorous approaches

Journal of High Energy Physics
In recent years, a surprisingly direct and simple rigorous understanding of quantum Liouville theory has developed. We aim here to make this material more accessible to physicists working on quantum field theory.
Sourav Chatterjee, Edward Witten
doaj   +1 more source