Results 101 to 110 of about 9,510,506 (294)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Laboratory and Field Evaluation of Cement-Stabilized Phyllite for Sustainable Railway Subgrades

open access: yesBuildings
Fully weathered phyllite is widely encountered along railway corridors in China, yet its suitability as subgrade fill remains insufficiently documented.
Aiping Chen   +7 more
doaj   +1 more source

A gap analysis of confined field trial application forms for genetically modified crops in East Africa: evaluating the potential for harmonization [PDF]

open access: yes
"The regulatory approval of genetically modified crops in the field initially requires small, restricted experimental trials known as confined field trials.
Cohen, Joel I., Linacre, Nicholas A.
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Summons of freeholders to Phillip's trial

open access: yes
This document is a legal writ issued by Samuel Dickinson and John Vining, two Justices of the Peace for Kent County. It outlines the commission assigned to Philip Brady (Bradey), a constable, to summon freeholders Benjamin Chew, Nathaniel Luff, Stephen ...
Kent County Court for the Trial of Negro Slaves
core   +2 more sources

Design and Experimental Operation of a Swing-Arm Orchard Sprayer

open access: yesAgronomy
In recent years, the traditional orchard sprayer has had problems, such as waste of liquid agrochemicals, low target coverage, high manual dependence, and environmental pollution.
Zhongyi Yu   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Phenotypic plasticity vs. local genetic adaptation: essential oil diversity of natural immortelle (Helichrysum italicum (Roth.) G.Don) populations along eastern Adriatic coast

open access: yesFrontiers in Plant Science
The essential oil of Helichrysum italicum (Roth) G.Don, commonly known as immortelle, is produced in Mediterranean countries to meet the increasing demand of the cosmetic and pharmaceutical industries.
Tonka Ninčević Runjić   +6 more
doaj   +1 more source

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