Results 81 to 90 of about 9,510,506 (294)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Design and Testing of a Soil-Removal Device for Peanut Harvesting in Saline–Alkali Soils: Using a Squeezing and Rubbing Method

Agriculture
In response to the pressing issues of unclear adhesion mechanisms during the soil-removal process in peanut harvesting, poor soil fragmentation quality, and difficulties in separating the pods from the soil.
Zengcun Chang, Dongwei Wang, Yu Tian, Xu Li, Baiqiang Zuo, Haipeng Yan, Jiayou Zhang, Jialin Hou, Dongjie Li   +8 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Integrated Field Evaluation of a Caseous Lymphadenitis Vaccine and Environmental Bacteriological Profiling in Commercial Goat Farms in South Korea

Vaccines
Background/Objectives: Caseous lymphadenitis (CLA), caused by Corynebacterium pseudotuberculosis, is difficult to control on goat farms because of subclinical infection, abscess rupture, environmental contamination, and repeated herd-level exposure. This
Gyeong-Seo Park, Somin Lee, Minsung Park, Minseok Kim, Eunhui Lee, Sungmin Lee, Myung Hyee Kim, Byeong Yeal Jung, Chonghan Kim, Byoung Joo Seo   +9 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Evaluation of sustainable asphalt concrete pavement with polyethylene terephthalate additive: performance, economic and environmental perspectives

Frontiers in Built Environment
This research evaluates the feasibility of incorporating reclaimed asphalt pavement (RAP) and polyethylene terephthalate (PET) waste into asphalt concrete with natural aggregate (NA) to improve performance while reducing costs and carbon footprint.
Apichat Suddeepong, Kongsak Akkharawongwhatthana, Suksun Horpibulsuk, Suksun Horpibulsuk, Menglim Hoy, Teerasak Yaowarat, Apinun Buritatum, Nantipat Pongsri, Karn Kantatham, Krirerk Aiamsri, Kanchana Hiranwatthan, Arul Arulrajah   +11 more
doaj   +1 more source

Field-Scale Experimental Designs and Spatial Econometric Methods for Precision Farming: Strip-Trial Designs for Rice Production Decision Making [PDF]

Site-specific data is spatially variable, precluding traditional econometric analysis. Some field-scale experimental designs present logistical, operational and mathematical problems in estimating treatment differences, specifically when adjacent ...
Florax, Raymond J.G.M., Griffin, Terry W., Lowenberg-DeBoer, James   +2 more
core  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Efficacy of a Calcium Functional Fertiliser with a Calcium Transport Stimulant in Managing Cavity Spot of Carrot (Daucus carota subsp. sativus)

International Journal of Plant Biology
The marketable yield of carrot is reduced by carrot cavity spot disease (Pythium violae and P. sulcatum). In the UK, metalaxyl-M is the only approved fungicide.
Jolyon Dodgson, Nicole Pereira, John Clarkson, Anna K. Marks, David J. Marks   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source