Results 61 to 70 of about 693,380 (314)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Quantifying potential carbon dioxide removal via enhanced weathering using porewater from a field trial in Scotland

Frontiers in Climate
Enhanced weathering (EW) is cited as a promising carbon dioxide removal (CDR) strategy, and is being rapidly commercialized. Rigorous monitoring, reporting and verification (MRV) are essential to ensure carbon claims are accurate and carbon credits are ...
Amy L. McBride, Kirstine Skov, Peter Wade, Joey Betz, Joey Betz, Amanda Stubbs, Tzara Bierowiec, Talal Albahri, Giulia Cazzagon, Chieh-Jhen Chen, Amy Frew, Matthew Healey, Ifeoma Idam, Lucy Jones, Mike E. Kelland, Jim Mann, David Manning, Callum Mitchell, Melissa J. Murphy, Anežka Radkova, Marta-Villa de toro Sanchez, Utku Solpuker, Yit Arn Teh, Rosalie Tostevin, Will Turner, Jez Wardman, Morven Wilkie, XinRan Liu   +27 more
doaj   +1 more source

Administration of non-pathogenic isolates of Escherichia coli and Clostridium perfringens type A to piglets in a herd affected with a high incidence of neonatal diarrhoea

Animal, 2017
A bacterial cocktail of living strains of Clostridium perfringens type A (CPA) without β2-toxin gene and non-pathogenic Escherichia coli was administered orally to newborn piglets before first colostrum intake and on 2 consecutive days on a farm with a ...
C. Unterweger, A. Kahler, G.-F. Gerlach, M. Viehmann, A. von Altrock, I. Hennig-Pauka   +5 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Comparison of the "Self - assessment" monitoring tool with "Routine supervisions" in maternal care services of urban health centers in Semnan, Iran

Payesh, 2003
Objective(s): Quality assessment based on client oriented approach is one of the most effective methods in improving efficacy of services. The "Self-assessment" consists   of four  monitoring  tools   including "service  assessment, client  flow ...
Madjdzadeh S.R, Sadighi J, Kolahdoz M, Younesian M, Noraei S.M, Jandaghi J, Norani N, Heidarian N, Malekinejad M, Abolhasani F, Askarinasab M, Emadi A, Farivar F, Asadi 0, Talebi A   +14 more
doaj  

Design and Testing of a Root–Soil Separation Device for Ophiopogon japonicus Harvesters Based on the Discrete Element Method

Agriculture
To address the challenges of separating roots from soil and the high soil carryover during harvesting of Ophiopogon japonicus in heavy clay soils, a variable-gap tooth roller chain-rod-and-slat separation device was designed, integrating variable-gap ...
Aichao Li, Min Wu, Lei Gao, Fuzeng Zhang, Quanhe Yang, Zhian Zheng   +5 more
doaj   +1 more source

Using single‐plant‐omics in the field to link maize genes to functions and phenotypes

Molecular Systems Biology, 2020
Most of our current knowledge on plant molecular biology is based on experiments in controlled laboratory environments. However, translating this knowledge from the laboratory to the field is often not straightforward, in part because field growth ...
Daniel Felipe Cruz, Sam De Meyer, Joke Ampe, Heike Sprenger, Dorota Herman, Tom Van Hautegem, Jolien De Block, Dirk Inzé, Hilde Nelissen, Steven Maere   +9 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Genome-Edited Fish in the Field

Current Issues in Molecular Biology
Genome editing using site-directed nucleases (SDNs), particularly with the CRISPR/Cas9 system, has emerged as a powerful platform for aquaculture innovation, enabling precise, heritable, and non-transgenic modifications that enhance productivity ...
Kang Hee Kho, Zahid Parvez Sukhan, Yusin Cho, Doohyun Cho, Cheol Young Choi   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source