Results 51 to 60 of about 693,380 (314)

Measuring late blight attack of potato foliage in field trials: optimal resource allocation in assessment trials

Journal für Kulturpflanzen, 2010
An empirical data set was analysed in order to give recommendations on the optimal resource allocation in a field testing system to measure late blight attack in potato.
Bernd Truberg, Thilo Hammann, Ulrich Darsow, Hans-Peter Piepho   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Polyethylene Glycol (PEG) Application Triggers Plant Dehydration but Does Not Accurately Simulate Drought

Plants
Polyethylene glycol (PEG), especially at high molecular weights, is highly soluble in water, and these solutions have reduced water potential. It is convenient to use PEG in hydroponics (liquid nutrient solution) for experiments with plants.
Gulnar Kylyshbayeva, Nazira Bishimbayeva, Sativaldy Jatayev, Serik Eliby, Yuri Shavrukov   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

First Real-Time 221.9 Pb/S∙Km Transmission Capability Demonstration Using Commercial 138-Gbaud 400 Gb/S Backbone OTN System over Field-Deployed Seven-Core Fiber Cable with Multiple Fusion Splicing

Photonics
The core-division-multiplexed (CDM) transmission technique utilizing uncoupled multi-core fiber (MCF) is considered a promising candidate for next-generation long-haul optical transport networks (OTNs) due to its high-capacity potential.
Jian Cui, Yu Deng, Zhuo Liu, Yuxiao Wang, Chen Qiu, Zhi Li, Chao Wu, Bin Hao, Leimin Zhang, Ting Zhang, Bin Wu, Chengxing Zhang, Weiguang Wang, Yong Chen, Kang Li, Feng Gao, Lei Shen, Lei Zhang, Jie Luo, Yan Sun, Qi Wan, Cheng Chang, Bing Yan, Ninglun Gu   +23 more
doaj   +1 more source

Bekämpfung von Beifußblättriger Ambrosie (Ambrosia artemisiifolia L.) in Mais, Getreide, Grünland und Nichtkulturland mit Herbiziden

Julius-Kühn-Archiv, 2014
In Brandenburg and Saxony numerous locations of Ambrosia artemisiifolia of low density have been reported. Furthermore there are, especially in the state Brandenburg, agricultural areas with a high density of A. artemisiifolia.
Meinlschmidt, Ewa, Schröder, Gerhard, Ullrich, Monique   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Bekämpfung von Zwischenfrüchten in Folgekulturen

Julius-Kühn-Archiv, 2020
Der Anbau von Zwischenfrüchten hat in vielfältiger Weise Einfluss auf das gesamte Anbausystem. So etwa in Hinblick auf die Speicherung von Nährstoffen, die Bildung von Humus, die Produktion von Biomasse, die Bekämpfung von Nematoden sowie den ...
Köhler, Lisa, Wolber, Dirk, Warnecke-Busch, Goßswinth   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source