Results 101 to 110 of about 127,012 (304)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

UNIFORMITY OF POTATO MINITUBERS DERIVED FROM MERISTEM CULTURES OF NUCLEAR SEED STOCKS

open access: yes, 2011
The uniformity of minitubers of meristem plantlets obtained from the meristems of nuclear seed stocks in the laboratory were studied in the greenhouse during 2008 and 2009. Tuber number per plant (TNP), tuber yield per plant (TVP) and single tuber weight
Yildirim, Zihin, Ozturk, Gulsum
core  

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe   +7 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Numerical simulation study on ultrasonic unplugging of coal fines plugging screen tube

open access: yesMeikuang Anquan
Aiming at the problem of coal fines plugging in the screen tube of coalbed methane wells, a two-dimensional and three-dimensional simulation models of the screen tube for coalbed methane wells were built with the help of COMSOL finite element simulation ...
Jinwei REN   +6 more
doaj   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi   +8 more
wiley   +1 more source

Improving The Performance of Center-Pivot Irrigation System

open access: yesJournal of Engineering and Sustainable Development, 2014
The main objective of this research is to elucidate the performance of moved center pivot sprinklers irrigation systems under different conditions, and examine the hydraulic uniformity coefficient according to (Heermann and Hein 2007) under different ...
Khalid Adel Abdelrazaq   +1 more
doaj  

Spacing uniformity - Yield effects and in-field measurement

open access: yes, 1996
Trials were done to investigate the effects of spacing uniformity on crop yield, and to assess a method of measuring spacing uniformity without the need to calculate the coefficient of variation.
Stephen Corkrey (14734306)   +3 more
core  

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