Results 131 to 140 of about 7,003,123 (311)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Interactions Between Trade Policy and Labor Market Policy and Their Effects on Development [PDF]
, 1986 [Excerpt] Studies of various countries show that those which have emphasized an export-led growth strategy have, in general, outperformed those which have followed an import substitution orientation.
Fields, Gary S
core +1 more source
Formalized MathematicsSummary We continue the formalization of field theory in Mizar. Here we prove existence and uniqueness of finite fields by constructing the splitting field of the polynomial X(pn) −X over the prime field of a field with characteristic p.
openaire +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Predicting Potential For Promotion: How The Data In Human Resource Information Systems Can Be Used To Help Organizations Gain Competitive Advantage [PDF]
, 2002 This paper utilizes the data contained in the Human Resources Information System (HRIS) of a company, called here “Engineering Solutions,” and analyzes the drivers of potential for promotion among a sample of engineers.
Fields, Gary S.
core +1 more source
Collegium antropologicum, 2013 This article is dedicated to main information about visual field, monocular and binocular ranges of visual field including their defects. Visual field loss may occur to disease of the eye, optic nerve or brain. Typical changes are present at glaucoma and macular degeneration. Visual pathway is also mentioned.
Sokolová Šidlová, Jana +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Earning Their Way out of Poverty (Outline and Sample Chapter) [PDF]
, 2010 [Excerpt] According to the latest figures, today an estimated 3.1 billion people still live in absolute poverty, essentially all of them in the low- and middle-income countries of Asia, Latin America, and Africa and none of them in what are traditionally
Fields, Gary S
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
The Potential Role of an Employment Guarantee Scheme in Korea\u27s Social Safety Net [PDF]
, 2001 [Excerpt] Beginning in November 1997, the Republic of Korea underwent a devastating economic crisis. Declining macroeconomic conditions brought about major labor market disruptions in 1998: a quadrupling of unemployment, a fall of 9% in real wages ...
Fields, Gary S
core +1 more source