Results 1 to 10 of about 226,046 (275)

On Including Pain as an Integral Part of the Fight-or-Flight Response [PDF]

Journal of Pain Research
Robert B Raffa,1,2 Wolfgang Fink,3 Anuj D Tripathi3 1Temple University (Emeritus), Philadelphia, PA, USA; 2University of Arizona (Adjunct), Tucson, AZ, USA; 3Visual and Autonomous Exploration Systems Research Laboratory, University of Arizona, Tucson, AZ,
Raffa RB, Fink W, Tripathi AD
doaj   +4 more sources

Rad regulation of Ca_V1.2 channels controls cardiac fight-or-flight response. [PDF]

Nat Cardiovasc Res, 2022
AbstractFight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. In the present study, we uncover the primary mechanism underlying the heart’s innate contractile reserve. We show that four protein kinase A (PKA)-phosphorylated residues in Rad, a calcium channel inhibitor, are crucial for controlling basal ...
Papa A, Zakharov SI, Katchman AN, Kushner JS, Chen BX, Yang L, Liu G, Jimenez AS, Eisert RJ, Bradshaw GA, Dun W, Ali SR, Rodriques A, Zhou K, Topkara V, Yang M, Morrow JP, Tsai EJ, Karlin A, Wan E, Kalocsay M, Pitt GS, Colecraft HM, Ben-Johny M, Marx SO.   +24 more
europepmc   +3 more sources

The role of stimulus-driven versus goal-directed processes in fight and flight tendencies measured with motor evoked potentials induced by Transcranial Magnetic Stimulation. [PDF]

PLoS ONE, 2019
This study examines two contrasting explanations for early tendencies to fight and flee. According to a stimulus-driven explanation, goal-incompatible stimuli that are easy/difficult to control lead to the tendency to fight/flee.
Agnes Moors, Chiara Fini, Tom Everaert, Lara Bardi, Evelien Bossuyt, Peter Kuppens, Marcel Brass   +6 more
doaj   +3 more sources

The fight-or-flight response is associated with PBMC expression profiles related to immune defence and recovery in swine. [PDF]

PLoS ONE, 2015
Defining phenotypes according to molecular features would promote the knowledge of functional traits like behaviour in both human and animal research.
Michael Oster, Mathias Scheel, Eduard Muráni, Siriluck Ponsuksili, Manuela Zebunke, Birger Puppe, Klaus Wimmers   +6 more
doaj   +2 more sources

Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response. [PDF]

Curr Mol Pharmacol, 2015
Intracellular calcium transients generated by activation of voltage-gated calcium (CaV) channels generate local signals, which initiate physiological processes such as secretion, synaptic transmission, and excitation-contraction coupling. Regulation of calcium entry through CaV channels is crucial for control of these physiological processes.
Catterall WA.
europepmc   +4 more sources

The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells. [PDF]

J Gen Physiol, 2022
The sympathetic nervous system fight-or-flight response is characterized by a rapid increase in heart rate, which is mediated by an increase in the spontaneous action potential (AP) firing rate of pacemaker cells in the sinoatrial node. Sympathetic neurons stimulate sinoatrial myocytes (SAMs) by activating β adrenergic receptors (βARs) and increasing ...
Peters CH, Rickert C, Morotti S, Grandi E, Aronow KA, Beam KG, Proenza C.   +6 more
europepmc   +5 more sources

Pavlovian to instrumental transfer of control over fight or flight decisions [PDF]

npj Science of Learning
This study investigated outcome-selective Pavlovian-to-instrumental transfer (PIT) in fight-or-flight decision making. Participants learned to attack or retreat from monsters (instrumental phase) and to associate environments with specific monsters ...
Andreas B. Eder, Vanessa Mitschke
doaj   +2 more sources

Crhr1 and epinephrine utilize the central Ras-MAPK pathway in mediating the acute stress-related locomotor activity in zebrafish larvae [PDF]

Frontiers in Endocrinology
IntroductionAlthough the Crh-Crhr1 system is the proximal trigger for the stressor-induced corticosteroid release, its role in initiating the fight-or-flight response to an acute stressor is unclear.
Enezi Khalid, Mathilakath M. Vijayan
doaj   +2 more sources

How Ca²⁺ influx is attenuated in the heart during a "fight or flight" response. [PDF]

J Gen Physiol, 2019
Bazmi and Escobar highlight a recent investigation of the mechanisms that regulate Ca2+ influx during sympathetic stimulation.
Bazmi M, Escobar AL.
europepmc   +7 more sources

Molecular mechanism of calcium channel regulation in the fight-or-flight response. [PDF]

Sci Signal, 2010
Stimulation of cardiac Ca 2+ channel activity by PKA in the fight-or-flight response requires an autoinhibitory complex with the distal C-terminal domain and a kinase anchoring protein.
Fuller MD, Emrick MA, Sadilek M, Scheuer T, Catterall WA.   +4 more
europepmc   +5 more sources