Results 41 to 50 of about 17,589 (258)

A Seven Amino Acid Long Region in the Cardiac Ca_v1.2, Encompassing Ser1487, Is Essential for Mice Embryonic Development and “Fight or Flight” Responses

Cells
The cardiac calcium channel Cav1.2 is essential for embryonic development, cardiac excitation–contraction coupling, and the “Fight or Flight” response. Regulation of Cav1.2 by protein kinase A (PKA) phosphorylation is critical to this process, though the
Catherine Jenkins, Henrietta Cserne Szappanos, Agnieszka Dyrda, Teagan S. Er, Filip van Petegem, Livia C. Hool   +5 more
doaj   +1 more source

The role of stimulus-driven versus goal-directed processes in fight and flight tendencies measured with motor evoked potentials induced by Transcranial Magnetic Stimulation.

PLoS ONE, 2019
This study examines two contrasting explanations for early tendencies to fight and flee. According to a stimulus-driven explanation, goal-incompatible stimuli that are easy/difficult to control lead to the tendency to fight/flee.
Agnes Moors, Chiara Fini, Tom Everaert, Lara Bardi, Evelien Bossuyt, Peter Kuppens, Marcel Brass   +6 more
doaj   +1 more source

Fight, Not Flight! Avoidant Goals Strengthen Attentional Biases During Increased Anxiety in Healthy Adults

Psychiatry International
Heightened anxiety can impair perceptual-motor performance, with detrimental effects potentially arising, in part, from threat-related attentional biases and interpretations.
Natsuki Sakemoto, Hideyuki Tanaka
doaj   +1 more source

Sexually dimorphic role of the locus coeruleus PAC1 receptors in regulating acute stress-associated energy metabolism

Frontiers in Behavioral Neuroscience, 2022
Severe stress leads to alterations in energy metabolism with sexually dimorphic onset or severity. The locus coeruleus (LC) in the brainstem that mediates fight-or-flight-or-freeze response to stress is sexually dimorphic in morphology, plays a key role ...
Samuel J. Duesman, Sanutha Shetty, Sanil Patel, Neha Ogale, Farzanna Mohamed, Njeri Sparman, Prashant Rajbhandari, Abha Karki Rajbhandari   +7 more
doaj   +1 more source

Calcium Channel Regulation in the Fight-Or-Flight Response [PDF]

Biophysical Journal, 2013
Voltage-gated calcium channel type 1.2 (Cav1.2) is activated in response to cardiac action potentials and conducts calcium entry that initiates excitation-contraction coupling. Cav1.2 activity is increased by stimulation of the beta-adrenergic receptor/cAMP-dependent protein kinase (PKA) signaling pathway in the fight-or-flight response.
openaire   +1 more source

Fight or flight? Potential tradeoffs between drought defense and reproduction in conifers. [PDF]

, 2019
Plants frequently exhibit tradeoffs between reproduction and growth when resources are limited, and often change these allocation patterns in response to stress.
Hart, Stephen C, Moran, Emily V, Lauder, Jeffrey D   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Repeated elicitation of the acoustic startle reflex leads to sensitisation in subsequent avoidance behaviour and induces fear conditioning

BMC Neuroscience, 2011
Background Autonomous reflexes enable animals to respond quickly to potential threats, prevent injury and mediate fight or flight responses. Intense acoustic stimuli with sudden onsets elicit a startle reflex while stimuli of similar intensity but with ...
Janik Vincent M, Götz Thomas
doaj   +1 more source

Stress-inducible IL-6 is regulated by KLF7 in brown adipocytes

Heliyon, 2023
Stress-inducible interleukin 6 (IL-6) is generated in brown adipocytes via beta-3 adrenergic receptor (ADRB3) signaling, which is necessary in stress hyperglycemia, the kind of metabolic adaptation enabling “fight or flight” response by means of liver ...
Yihan Tang, Dingling Ma, Maodi Liang, Yanting Hou, Meixiu Zhang, Jingzhou Wang, Chenggang Yuan, Menghuan Li, Chaoyue Sun, Jianxin Xie, Cuizhe Wang, Jun Zhang   +11 more
doaj   +1 more source