Results 131 to 140 of about 9,244 (259)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

'It is not my business': Adolescent boys' experiences and responses to community violence in Soweto, South Africa. [PDF]

J Child Adolesc Trauma
Zharima C, Mboneli E, Tsotetsi L, Vermaak S, Nkala B, Violari A, Kidman R, Hammock A, Dietrich J.   +8 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Detection of Financial Toxicity in Italian Uremic Patients: A Single Center Cross-Sectional Study. [PDF]

Int J Nephrol Renovasc Dis
Di Maria A, Capone M, Mancini R, De Giorgi A, Gavazzoli E, Scichilone LM, Veronesi M, Nicoletti S, Fabbian F.   +8 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Doctor, Reconstructed. [PDF]

Fam Med
Cavin J.
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Forging Hopeful Futures Community-Partnered Violence Prevention Intervention: Protocol for a Comparative Effectiveness Trial. [PDF]

JMIR Res Protoc
Culyba AJ, Pulerwitz J, Ajith A, Barrett S, Blankenship K, Chin A, Hanner CD, Henry C, Klotz S, Koranteng-Yorke N, Minter K, Mixson R, Mumin D, Sabia A, Sierra E, Saur N, Wilson T, Gottert A.   +17 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From invisibility to political power: Policy lessons from a decade of Brazil's Social Forum for Infectious and Neglected Diseases. [PDF]

PLoS Negl Trop Dis
Pinheiro EDS, Araújo CEL, Cunha ESM, Rocha AMD, Lopes Nunes Galvão D, Souza EA, da Silva MPCAM, Ramos AN.   +7 more
europepmc   +1 more source