Results 111 to 120 of about 12,963 (306)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

A Profile of the Limpopo Province: Demographics, Poverty, Inequality, and Unemployment [PDF]

open access: yes
This paper forms part of a series of papers that present profiles of South Africa's provinces, with a specific focus on key demographic statistics, poverty and inequality estimates, and estimates of unemployment. In this volume comparative statistics are
Pauw, Kalie
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

The challenges to the consolidation of Brazil’s international prominence: education and culture

open access: yesRevista CIDOB d'Afers Internacionals, 2012
Over the last years, Brazil has gained international visibility especially due to the capacity of its economical development and the progress of its public policies on fighting poverty.
Elizabete Sanches Rocha
doaj  

We Know How to Fight Poverty. So Let's Fight [PDF]

open access: yesAcademic Pediatrics, 2021
Richard, Besser   +2 more
openaire   +2 more sources

A Profile of the Free State Province: Demographics, Poverty, Inequality and Unemployment [PDF]

open access: yes
This paper forms part of a series of papers that present profiles of South Africa's provinces, with a specific focus on key demographic statistics, poverty and inequality estimates, and estimates of unemployment. In this volume comparative statistics are
Pauw, Kalie
core   +1 more source

Poverty alleviation initiatives. Vol. 11, No. 3, July - September 2001 [PDF]

open access: yes, 2001
Eminent Asian leaders met to explore new agenda for Asia ... 1 Organic agriculture – a strategy for sustainable rural livelihoods in Asia? ... 4 UNDP extends support in fighting poverty in Thailand ...
UN.ESCAP
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

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